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Doramectin

Chemical compound


Chemical compound

| Drugs.com =

| elimination_half-life =

  • 25-cyclohexylavermectin B1,
  • 25-cyclohexyl-25-de(l-methylpropyl)avermectin B1a,
  • 25-cyclohexyl-5-O-demethyl-25-de(l-methylpropyl)avermectin A1a}}

Doramectin, sold under the brand name Dectomax among others, is a veterinary medication approved by the US Food and Drug Administration (FDA) for the treatment of parasites such as gastrointestinal roundworms, lungworms, eyeworms, grubs, sucking lice, and mange mites in cattle. It is available as a generic medication. It is available as a combination with levamisole under the brand name Valcor.

It is used for the treatment and control of internal parasitosis (gastrointestinal and pulmonary nematodes), ticks and mange (and other ectoparasites). Doramectin is a derivative of avermectin. Similarly to other drugs of this family, it is produced by fermentation by selected strains of Streptomyces avermitilis followed by chemical modification. Its spectrum includes: Haemonchus, Ostertagia, Trichostrongylus, Cooperia, and Oesophagostomum species and Dictyocaulus viviparus, Dermatobia hominis, Boophilus microplus, and Psoroptes bovis, among many other internal and external parasites. It is available as an injection and as a topical solution.

Society and culture

In November 2024, the FDA approved doramectin (brand name Doracide) for the treatment and control of gastrointestinal roundworms, lungworms, eyeworms, grubs, biting and sucking lice, horn flies, and mange mites in cattle.

Brand names

Doramectin is marketed under the brand name Doramec L.A. for cattle, sheep, and swine.

Doramectin is available for horses as an oral, flavored, bioadhesive gel under the name Doraquest L.A. Oral Gel. It can be used to control and treat internal parasites as roundworms, lungworms and some external parasites.

References

References

  1. (13 September 2022). "Dectomax- doramectin injection, solution".
  2. (5 August 2022). "Dectomax Pour-On- doramectin solution".
  3. (11 January 2023). "FDA Approves First Generic Doramectin for Use in Cattle".
  4. "Animal Drugs @ FDA".
  5. (July 1993). "Doramectin--a potent novel endectocide". Veterinary Parasitology.
  6. (2 December 2024). "Recent Animal Drug Approvals".
  7. [https://animaldrugsatfda.fda.gov/adafda/app/search/public/document/downloadFoi/16286 fda.gov]
Info: Wikipedia Source

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