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Diphenylmethanol

Diphenylcarbinol Hydroxydiphenylmethane

Diphenylmethanol is the organic compound with the formula (C6H5)2CHOH. Also known as benzhydrol, it is a white solid and the parent member of a large class of diaryl alcohols.

Preparation

Diphenylmethanol may be prepared by a Grignard reaction between phenylmagnesium bromide and benzaldehyde. An alternative method involves reducing benzophenone with sodium borohydride or with zinc dust or with sodium amalgam and water.

Uses and safety

It has uses in perfume and pharmaceutical manufacture. In perfumery it is used as a fixative. In pharmaceutical manufacture it is used in the synthesis of antihistamines / antiallergenic agents and antihypertensive agents . It is used in the synthesis of modafinil{{Cite patent|country=EP|number=1583739|title=Method for preparing methyl 2-diphenylmethylsulfinylacetate|pubdate=2005-10-12 |inventor1-last=Rose |inventor1-first=Sebastien |inventor2-last=Klein |inventor2-first=Dominique

Diphenylmethanol is an irritant to the eyes, skin and respiratory system.

References

[http://www.pcl.ox.ac.uk/MSDS/DI/diphenylmethanol.html MSDS]{{Dead link. (July 2019)
"Diphenylmethanol".
(1928). "Benzohydrol".

Info: Wikipedia Source

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secondary-alcohols benzhydryl-compounds

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