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Desoxy (psychedelic)

Field	Value
verifiedrevid	414403090
drug_name	Desoxy
image	DESOXY.png
image_class	skin-invert-image
width	225px
image2	DESOXY-3d-sticks.png
image_class2	bg-transparent
width2	200px
routes_of_administration	Oral
class	Serotonergic psychedelic; Hallucinogen
ATC_prefix	None
duration_of_action	6–8 hours
CAS_number_Ref
CAS_number	63037-49-0
PubChem	44350128
ChemSpiderID_Ref
ChemSpiderID	21106289
UNII_Ref
UNII	424LJJ87HT
ChEMBL_Ref
ChEMBL	127679
synonyms	4-Methyl-3,5-dimethoxyphenethylamine; 3,5-Dimethoxy-4-methylphenethylamine
IUPAC_name	2-(3,5-dimethoxy-4-methylphenyl)ethan-1-amine
C	11	H=17	N=1	O=2
SMILES	Cc1c(cc(cc1OC)CCN)OC
StdInChI_Ref
StdInChI	1S/C11H17NO2/c1-8-10(13-2)6-9(4-5-12)7-11(8)14-3/h6-7H,4-5,12H2,1-3H3
StdInChIKey_Ref
StdInChIKey	LLHRMWHYJGLIEV-UHFFFAOYSA-N

| Drugs.com =

| elimination_half-life =

Desoxy, or DESOXY, also known as 4-desoxymescaline or as 4-methyl-3,5-dimethoxyphenethylamine, is a psychedelic drug of the phenethylamine and scaline families related to mescaline (3,4,5-trimethoxyphenethylamine). It is the analogue of mescaline in which the methoxy group at the 4 position has been replaced with a methyl group, hence an oxygen has been removed and the name "desoxy". The drug was first described in the scientific literature by F. Benington and colleagues in 1960. Subsequently, it was described in greater detail by Alexander Shulgin in his 1991 book PiHKAL (Phenethylamines I Have Known and Loved) and other publications.

Use and effects

A typical dose is within the range of 40 to 120mg orally and lasts 6 to 8hours. The effects of DESOXY vary significantly from mescaline, despite their chemical similarity. Its effects included closed-eye imagery but no open-eye visuals.

Interactions

Pharmacology

Pharmacodynamics

DESOXY acts as a serotonin 5-HT2 receptor agonist.

Society and culture

Legal status

Canada

Desoxy is not a controlled substance in Canada as of 2025.

United States

In 1970 the Controlled Substances Act placed mescaline into Schedule I in the United States. It is similarly controlled in other nations. Depending on whether or not it is intended for human consumption, 4-desoxymescaline could be considered an analogue of mescaline, under the Federal Analogue Act and similar bills in other countries, making it illegal to manufacture, buy, possess, or distribute without a DEA or related license. DESOXY is also an isomer of 2C-D which makes it a schedule 1 drug in the United States.

References

(2011). "The Shulgin Index, Volume One: Psychedelic Phenethylamines and Related Compounds". [[Transform Press]].
(1960). "Notes- Mescaline Analogs. X. 3,4-Dimethyl-, 3,4-Dichloro- and 3,5-Dimethoxy-4-methyl-β-phenethylamines". The Journal of Organic Chemistry.
(September 1991). "PiHKAL: A Chemical Love Story". Transform Press.
(December 2023). "Identification of 5-HT_2A receptor signaling pathways associated with psychedelic potential". Nature Communications.
"Controlled Drugs and Substances Act".

Info: Wikipedia Source

This article was imported from Wikipedia and is available under the Creative Commons Attribution-ShareAlike 4.0 License. Content has been adapted to SurfDoc format. Original contributors can be found on the article history page.

5-ht2a-agonists 5-ht2b-agonists 5-ht2c-agonists pihkal psychedelic-phenethylamines scalines

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