Delmadinone acetate

Uses

Veterinary

Delmadinone acetate (DMA) is used in veterinary medicine to treat androgen-dependent conditions in animals. Its most common use is for the treatment of benign prostatic hyperplasia in male dogs. It may also be prescribed for managing hypersexuality in male dogs and cats, perianal gland tumors in dogs, and hormone-driven aggression in dogs.

Pharmacology

Pharmacodynamics

Delmadinone acetate (DMA) is a progestogen with antigonadotropic, and therefore antiandrogenic and antiestrogenic, effects. In addition, DMA binds to the androgen receptor and is thought to act as an antagonist of this receptor, similarly to related drugs such as chlormadinone acetate and osaterone acetate.

Chemistry

Delmadinone acetate (DMA), also known as 1-dehydrochlormadinone acetate, 1,6-didehydro-6-chloro-17α-acetoxyprogesterone, or 6-chloro-17α-hydroxypregna-1,4,6-triene-3,20-dione, is a synthetic pregnane steroid and a derivative of progesterone. It is specifically a 17α-hydroxyprogesterone derivative, characterized by the presence of a chlorine atom at the C6 position, a double bond between the C1 and C2 positions, another double bond between the C6 and C7 positions, and an acetate ester at the C17α position. Structural analogues of DMA include other 17α-hydroxyprogesterone derivatives such as chlormadinone acetate, cyproterone acetate, hydroxyprogesterone caproate, medroxyprogesterone acetate, megestrol acetate, and osaterone acetate.

History

Delmadinone acetate (DMA) was first described in the scientific literature in 1959 and has been marketed since at least 1972. By that time, it was marketed in Europe and the United Kingdom under the brand names Tardak and Zenadrex. It was also under development for use in the United States, but it does not appear to have been marketed there.

Society and culture

Generic names

Delmadinone acetate is the generic name of the drug and its and . Delmadinone is the and of the unesterified free alcohol form.

Brand names

DMA is most commonly marketed under the brand name Tardak, but has also been sold under several other brand names, including Delmate, Estrex, Tardastren, Tardastrex, Vetadinon, and Zenadrex.

Availability

DMA is available in Europe and Oceania. It is marketed specifically in the United Kingdom, France, Belgium, Germany, Austria, Switzerland, the Netherlands, Finland, Australia, and New Zealand.

References

References

1. (14 November 2014). "The Dictionary of Drugs: Chemical Data, Structures and Bibliographies". Springer.
2. (2000). "Index Nominum 2000: International Drug Directory". Taylor & Francis US.
3. (1999). "Concise Dictionary of Pharmacological Agents: Properties and Synonyms". Springer.
4. "List of Progestins". Drugs.com.
5. (August 1998). "Effects of delmadinone acetate on pituitary-adrenal function, glucose tolerance and growth hormone in male dogs". Australian Veterinary Journal.
6. (2008). "Update on medical management of benign prostatic hyperplasia". Companion Animal.
7. (May 2008). "Structure-activity relationships of synthetic progestins in a yeast-based in vitro androgen bioassay". The Journal of Steroid Biochemistry and Molecular Biology.
8. (1959). "Steroids. CXXVII. 16-Halo Progestational Agents". Journal of the American Chemical Society.
9. (1972). "Modern Veterinary Practice".