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Delapril

Chemical compound

| Drugs.com =

| elimination_half-life =

Delapril (INN, also known as alindapril) is an ACE inhibitor used as an antihypertensive drug in some European and Asian countries but not in America. It is taken orally, available in 15 mg and 30 mg tablets.

Mechanism

Delapril is a prodrug; it is converted into two active metabolites, 5-hydroxy delapril diacid and delapril diacid. These metabolites bind completely to and inhibit angiotensin-converting enzyme (ACE), hence blocking angiotensin I to angiotensin II conversion. The resulting vasodilation prevents the vasoconstrictive effects of angiotensin II. Angiotensin II-induced aldosterone secretion by the adrenal cortex is also decreased by Delapril, leading to increases in excretion of sodium and therefore increases water outflow.

References

(2007). "Manidipine-delapril combination in the management of hypertension". Vascular Health and Risk Management.
"Delapril". Drugs.com.
"Delapril".
"Delapril". U.S. National Library of Medicine.

Info: Wikipedia Source

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2-aminoindanes ace-inhibitors acetic-acids enantiopure-drugs ethyl-esters prodrugs propionamides drugs-developed-by-takeda-pharmaceutical-company

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