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D-161

Chemical compound

Chemical compound

D-161 is a chemical known in research circles as a triple reuptake inhibitor. Although this compound has lent support to the inclusion of dopamine in the monoamine hypothesis of depression, D-161 has not been tested in clinical trials.

A more recent study was reported.

A couple of patents are also disclosed.

Synthesis

The synthesis of this agent has been reported.

References

References

  1. (July 2008). "D-161, a novel pyran-based triple monoamine transporter blocker: behavioral pharmacological evidence for antidepressant-like action". European Journal of Pharmacology.
  2. (January 2014). "Flexible and biomimetic analogs of triple uptake inhibitor 4-((((3S,6S)-6-benzhydryltetrahydro-2H-pyran-3-yl)amino)methyl)phenol: Synthesis, biological characterization, and development of a pharmacophore model". Bioorganic & Medicinal Chemistry.
  3. Aloke K. Dutta, WO2005105075 (Wayne State University).
  4. Aloke K. Dutta, US8017791 (2011 to Wayne State University).
  5. (1 July 2006). "Further Structural Exploration of Trisubstituted Asymmetric Pyran Derivatives (2 S ,4 R ,5 R )-2-Benzhydryl-5-benzylamino-tetrahydropyran-4-ol and Their Corresponding Disubstituted (3 S ,6 S ) Pyran Derivatives: A Proposed Pharmacophore Model for High-Affinity Interaction with the Dopamine, Serotonin, and Norepinephrine Transporters". Journal of Medicinal Chemistry.
  6. (28 April 2011). "Further Structure−Activity Relationship Studies on 4-((((3 S ,6 S )-6-Benzhydryltetrahydro-2 H -pyran-3-yl)amino)methyl)phenol: Identification of Compounds with Triple Uptake Inhibitory Activity as Potential Antidepressant Agents". Journal of Medicinal Chemistry.
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serotonin–norepinephrine–dopamine-reuptake-inhibitors 4-hydroxyphenyl-compounds tetrahydropyrans
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