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Corticotropin-like intermediate peptide

Field	Value
Name	pro-opiomelanocortin
image	Corticotropin-like intermediate peptide.svg
HGNCid	9201
Symbol	POMC
EntrezGene	5443
OMIM	176830
RefSeq	NM_000939
UniProt	P01189
Chromosome	2
Arm	p
Band	23

Corticotropin-like intermediate [lobe] peptide (CLIP), also known as adrenocorticotropic hormone fragment 18-39 (ACTH(18-39)), is a naturally occurring, endogenous neuropeptide with a docosapeptide structure and the amino acid sequence Arg-Pro-Val-Lys-Val-Tyr-Pro-Asn-Gly-Ala-Glu-Asp-Glu-Ser-Ala-Glu-Ala-Phe-Pro-Leu-Glu-Phe. CLIP is generated as a proteolyic cleavage product of adrenocorticotropic hormone (ACTH), which in turn is a cleavage product of proopiomelanocortin (POMC). Its physiological role has been investigated in various tissues, specifically in the central nervous system.

It has been suggested to function as an insulin secretagogue in the pancreas.

References

(December 1979). "Biosynthesis and characterization of adrenocorticotropic hormone, alpha-melanocyte-stimulating hormone, and an NH2-terminal fragment of the adrenocorticotropic hormone/beta-lipotropin precursor from rat pars intermedia". The Journal of Biological Chemistry.
Lloyd D. Fricker. (24 July 1991). "Peptide biosynthesis and processing". CRC Press.
(26 September 1997). "Hormones". Academic Press.
(November 1984). "Effect of corticotropin-like intermediate lobe peptide on pancreatic exocrine function in isolated rat pancreatic lobules". The Journal of Clinical Investigation.
(January 1991). "Immunohistochemical distribution of corticotropin-like intermediate lobe peptide (CLIP) immunoreactivity in the human brain". Brain Research Bulletin.
(1989). "Biology of sleep substances". CRC Press.
(February 1990). "Proopiomelanocortin (POMC)-derived peptides and sleep in the rat. Part 1--Hypnogenic properties of ACTH derivatives". Neuropeptides.
(February 1990). "Proopiomelanocortin (POMC)-derived peptides and sleep in the rat. Part 2--Aminergic regulatory processes". Neuropeptides.
(March 2009). "Effect of corticotropin-like intermediate lobe peptide on presynaptic and postsynaptic glutamate receptors and postsynaptic GABA receptors in rat brain". Bulletin of Experimental Biology and Medicine.
(1993). "Neuronal transmission of hippocampal CA1 neurones is modulated by corticotropin-like intermediate lobe peptide [CLIP; ACTH(18-39)]". Peptides.
(November 1984). "Effect of corticotropin-like intermediate lobe peptide on pancreatic exocrine function in isolated rat pancreatic lobules". The Journal of Clinical Investigation.

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