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Copper ibuprofenate

| NFPA-H = | NFPA-F = | NFPA-R = | NFPA-S = Ibuprofen}} Copper ibuprofenate is a coordination complex consisting of copper(II) and the conjugate base of ibuprofen. The compound is prepared by the reaction of sodium ibuprofenate with copper(II) sulfate.

Copper ibuprofenate adopts a typical Chinese lantern structure, as seen for many transition metal carboxylate complexes. X-ray crystallography reveals a polymer with a bonding motif very similar to that of copper(II) trifluoroacetate.

It has been suggested that copper complexes of anti-inflammatory drugs are more active than the parent drug and produce fewer gastrointestinal side-effects. In 2008, a United States patent was issued for the utilization of ibuprofenate complexes (including copper ibuprofenate) as a wood preservative.{{US patent reference | issue-date = 2007-07-26

References

References

  1. (2024). "Ibuprofen: A multi-purpose active pharmaceutical ingredient as versatile ligand for zinc(II) and copper(II). Solid state and solution studies". Inorganica Chimica Acta.
  2. Frazier, D. R.. (1981). "Synthesis and magnetic properties of bis[2-(4-isobutylphenyl)propionato]copper(II)". Journal of Inorganic and Nuclear Chemistry.
  3. Abuhijleh AL. (September 1994). "Mononuclear and binuclear copper(II) complexes of the antiinflammatory drug ibuprofen: synthesis, characterization, and catecholase-mimetic activity". J. Inorg. Biochem..
  4. Sorenson JR. (1989). "Copper complexes offer a physiological approach to treatment of chronic diseases". Prog Med Chem.
  5. (May 2005). "Immobilization of ibuprofen and copper-ibuprofen drugs on layered double hydroxides". J Pharm Sci.
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