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Copper aspirinate

Copper aspirinate

|Copper, tetrakis[mu-[2-(acetyloxy)benzoato-kappaO:kappaO']]di- |tetrakis-μ-acetylsalicylato-dicopper(II) |copper(II) aspirinate |cupric acetylsalicylate |cupric aspirinate |cupric aspirin complex | NFPA-H = | NFPA-F = | NFPA-R = | NFPA-S =

Copper(II) aspirinate is an aspirin chelate of copper(II) cations (). It is used to treat rheumatoid arthritis.

Picture of copper(II) aspirinate

Preparation

Copper aspirinate can be prepared by several methods. In one route of preparation, an excess of acetylsalicylic acid is dissolved in aqueous sodium carbonate. Sodium hydroxide is not suitable for this purpose, because it will hydrolyse acetylsalicylic acid (ASA) into salicylic acid and sodium acetate.

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The resulting solution is then filtered to remove any undissolved acetylsalicylic acid and is mixed with a solution containing cations (copper(II) sulfate is suitable), precipitating bright blue crystals of copper aspirinate immediately. The crystals can then be filtered from solution, washed, and dried. An excess of acetylsalicylic acid is used in the first step, because it eliminates the possibility of unreacted carbonate anions precipitating the copper in this step.

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Medicinal use

Copper aspirinate has been proven effective as a treatment for rheumatoid arthritis. A pharmacokinetic study in healthy human volunteers supports its enhanced efficacy as compared with aspirin. The studies on animal models suggest that copper aspirinate is very promising in treating against thrombotic diseases and it has all the prospects of success in becoming an antithrombotic drug that prevents and treats thrombotic diseases in humans.

Other uses

The use of copper aspirinate as a pigment in PVC and polystyrene has also been investigated.

Footnotes

References

  1. {{PGCH. 0150
  2. PubChem. "Copper, tetrakis[mu-[2-(acetyloxy)benzoato-kappaO:kappaO']]di-".
  3. (June 2000). "Rheumatoid Arthritis (RA)". Copper Development Association.
  4. (September 2008). "Pharmacokinetic Study of Copper (II) Acetylsalicylate". Biological Trace Element Research.
  5. (1998). "Potential Application of Copper Aspirinate in Preventing and Treating Thromboembolic Diseases". Metal-Based Drugs.
  6. (1991). "A Study of the Performance of Bis(acetylsalicylate) Copper(II) and the Cobalt(II), Nickel(II) and Copper(II) Complexes of Pyridine-3,4-dicarboxylic Acid as Colouring Materials for Poly(vinyl chloride) and Polystyrene". Eur. Polym. J..
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copper(ii)-compounds acetylsalicylic-acids salicylates
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