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Colforsin daropate

Chemical compound

Chemical compound

| Drugs.com =

| elimination_half-life =

Colforsin daropate is a cardiovascular drug used to treat acute heart failure. Chemically, it is a carboxylic ester derived from the condensation of forskolin (colforsin) with N,N-dimethyl-β-alanine.

Its water-soluble hydrochloride salt (NKH 477) is an adenylyl cyclase activator which has been studied for its cardiac selectivity.

Colforsin daropate has been studied for its potential to be repurposed for the treatment of some types of cancer.

References

References

  1. "Colforsin daropate". AdisInsight.
  2. "colforsin daropate". EMBL-EBI.
  3. "β-Alanine, ''N'',''N''-dimethyl-, (3''R'',4a''R'',5''S'',6''S'',6a''S'',10''S'',10a''R'',10b''S'')-5-(acetyloxy)-3-ethenyldodecahydro-10,10b-dihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-1''H''-naphtho[2,1-b]pyran-6-yl ester, hydrochloride (1:1)". American Chemical Society.
  4. (August 1994). "Effect of NKH477, a new water-soluble forskolin derivative, on arterial-ventricular coupling and mechanical energy transduction in patients with left ventricular systolic dysfunction: comparison with dobutamine". Journal of Cardiovascular Pharmacology.
  5. (July 1995). "Effects of NKH477, a water-soluble forskolin derivative, on cardiac function in rats with chronic heart failure after myocardial infarction". The Journal of Pharmacology and Experimental Therapeutics.
  6. (November 2024). "Repurposing colforsin daropate to treat MYC-driven high-grade serous ovarian carcinomas". Science Signaling.
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