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Clofoctol

Chemical compound

Chemical compound

4-(2,4,4-trimethylpentan-2-yl)phenol

| Drugs.com =

| elimination_half-life =

Clofoctol is a bacteriostatic antibiotic. It is used in the treatment of respiratory tract and ear, nose and throat infections caused by Gram-positive bacteria. It has been marketed in France till 2005 under the trade name Octofene and in Italy as Gramplus.

It is only functional against Gram-positive bacteria.

It penetrates into human lung tissue.

A French company, Apteeus had been developing clofoctol as a potential therapy against SARS-CoV-2 in 2020-2021, but eventually the repurposing of the drug was abandoned, due to a lack of volunteers. A mouse study showed repurposed drug clofoctol blocks SARS-CoV-2 replication.

References

References

  1. (July 25, 2007). "Gramplus". Studio Medico Torrino.
  2. (1980). "[Clofoctol binding by the bacteria (author's transl)]". Journal de Pharmacologie.
  3. (1988). "A pharmacokinetic study of clofoctol in human plasma and lung tissue by using a microbiological assay". Drugs Under Experimental and Clinical Research.
  4. (2020-10-13). "Pasteur Lille obtient 5 M€ de LVMH pour repositionner un ancien médicament, l'Octofene, sur le traitement du Covid". AEF info.
  5. (2021-09-13). "La piste clofoctol. Interview du Pr Xavier Nassif". Jim.fr.
  6. (2021-05-21). "Hope for an Anti-COVID Drug". ARTE G.E.I.E..
  7. (2022-07-04). "La molécule miracle !".
  8. (2020-10-01). "French institute aims to start human trials of 'promising' Covid-19 drug this winter".
  9. (2020-06-20). "Covid-19: un reportage sur les chercheurs de l'institut Pasteur de Lille ce samedi sur Arte".
  10. (2022-05-23). "Repurposed drug clofoctol blocks SARS-CoV-2 replication in mouse study".
  11. (May 2022). "Clofoctol inhibits SARS-CoV-2 replication and reduces lung pathology in mice". PLOS Pathogens.
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antibiotics phenols chloroarenes
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