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CL-218,872

Chemical compound

Chemical compound

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CL-218,872 is a sedative and hypnotic drug used in scientific research. It has similar effects to sedative-hypnotic benzodiazepine drugs such as triazolam, but is structurally distinct and so is classed as a nonbenzodiazepine hypnotic.

CL-218,872 is a GABAA partial agonist which is selective for the α1 subtype. It has a range of effects including sedative, hypnotic, anxiolytic, anticonvulsant and amnestic actions, however the most prominent actions are sedation and amnesia, and CL-218,872 produces effects very similar to those of the hypnotic imidazopyridine derivative zolpidem in animal studies.

References

References

  1. (July 1994). "Synthesis and anticonvulsant properties of new benzylpyridazine derivatives". Journal of Medicinal Chemistry.
  2. (August 1994). "Bicyclic [b]-heteroannulated pyridazine derivatives--II. Structure-activity relationships in the 6-aryltriazolo-[4,3-b]pyridazine ligands of the benzodiazepine receptor". Bioorganic & Medicinal Chemistry.
  3. (November 1995). "Expression and pharmacology of human GABAA receptors containing gamma 3 subunits". European Journal of Pharmacology.
  4. (November 1996). "Molecular and pharmacological characterization of native cortical gamma-aminobutyric acidA receptors containing both alpha1 and alpha3 subunits.". Journal of Biological Chemistry.
  5. (March 1999). "Regional differences in the inhibition of mouse in vivo [3H]Ro 15-1788 binding reflect selectivity for alpha 1 versus alpha 2 and alpha 3 subunit-containing GABAA receptors". Neuropsychopharmacology.
  6. (January 2003). "Discriminative stimulus effects of zolpidem in squirrel monkeys: role of GABA(A)/alpha1 receptors". Psychopharmacology.
  7. (December 2003). "Spatial learning deficits induced by muscimol and CL218,872: lack of effect of prenatal malnutrition". Nutritional Neuroscience.
  8. (March 2006). "Comparative cue generalization profiles of L-838, 417, SL651498, zolpidem, CL218,872, ocinaplon, bretazenil, zopiclone, and various benzodiazepines in chlordiazepoxide and zolpidem drug discrimination". The Journal of Pharmacology and Experimental Therapeutics.
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sedatives triazolopyridazines trifluoromethyl-compounds gabaa-receptor-positive-allosteric-modulators
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