CimaVax-EGF

Mechanism

CimaVax is an active vaccine with which patients are immunized with epidermal growth factor (EGF), thus raising antibodies targeting EGF itself. The EGF is chemically linked to the Neisseria meningitidis outer protein P64k for immunogenicity; The epidermal growth factor receptor (EGFR) is hijacked by many types of cancer, including cancers of the lung, colon, kidney, and head and neck. By raising antibodies against EGF, which is EGFR's major ligand, the concentrations of EGF in the blood are reduced. Thus CimaVax does not target the cancer cells directly, but is expected to work against these cancers by denying the cancers the growth stimulus they require. For this reason, the Roswell Park Comprehensive Cancer Center group thinks that it may prove most useful as a preventive vaccine rather than as a cancer therapy per se.

Research

Cuba

Early trials showed a trend towards improved survival among vaccinated test subjects. A direct correlation between the level of antibodies that a vaccinated patient raises against EGF and survival has been observed in several trials, and in one of the largest trials there was also an age-dependence, with only subjects under the age of 60 benefiting in terms of survival. More antibodies are raised when the vaccine is formulated with Montanide ISA 51 rather than aluminum hydroxide as an adjuvant, and when patients receive a low dose of cyclophosphamide three days before vaccine administration. Cyclophosphamide is thought to temporarily block the body's natural immune tolerance to EGF, thereby increasing antibody titers.

Researchers caution that the early results to date have been in relatively small, early-stage trials with patients that were carefully selected based on predefined inclusion and exclusion criteria, and given specialized oncology care; they may therefore not be representative of most patients who might benefit from the vaccine. It has been urged that CimaVax be tested in patients with earlier-stage NSCLC cancer and in patients who are not candidates for chemotherapy, and that research be conducted to determine which subgroups of NSCLC patients do and don't respond to the vaccine. It has been suggested that CimaVax may also be effective in other types of cancer that are dependent on EGF/EGFR, including many cases of prostate cancer.

In Cuba, CimaVax-EGF has completed a phase IV clinical trial for NSCLC in 2017. It is approved as a "maintenance treatment for patients with stage IIIB/IV NSCLC".

International

The United States embargo against Cuba forbids US citizens from seeking medical treatment in Cuba. However, some cancer patients from the US have defied the embargo and travelled to Cuba for treatment with CimaVax.

Trials are being organized in the United States, the European Union, Japan, Roswell Park Comprehensive Cancer Center to conduct a PhaseI/II clinical trial of CimaVAX in patients with non-small cell lung cancer. By the middle of the following month, nearly 200 people had volunteered to be subjects in the trial.

In September 2018, Principal Investigator Grace Dy shared the initial results of the first Roswell Park trial. They found that the combination of CIMAvax with the PD-1 inhibitor checkpoint inhibitor nivolumab was safe and well tolerated in 13 people with advanced non-small cell lung cancer (NSCLC) when administered at the doses normally recommended for each agent individually. Notably, they observed durable responses to the combination treatment in patients who were unlikely to benefit from nivolumab alone due to low tumor levels of PD-L1, suggesting that the combination may work better than either agent individually.

The final results of this early trial were released in March 2019. The results were in line with the September 2018 report, with the additional finding that patients receiving combination therapy in this trial were more likely to develop robust early antibody responses to CIMAvax as compared with what had been observed in earlier studies with CIMAvax alone.

An ongoing Phase II clinical trial (clinicaltrials.gov identifier NCT02955290) has been expanded to include patients with advanced, recurrent head and neck squamous-cell carcinoma, as well as patients with advanced NSCLC but with high PD-L1 levels, who will be treated with pembrolizumab in combination with CIMAvax instead of nivolumab. As of 2023, accrual for this phase II trial is ongoing.

References

References

1. "RESOLUCIÓN No. 2016006539 DE 25 de Febrero de 2016 Por la cual se concede un Registro Sanitario". República de Colombia Ministerio de Salud y Protección Social Instituto Nacional de Vigilancia de Medicamentos y Alimentos – INVIMA.
2. (2015). "CIMAvax EGF (EGF-P64K) vaccine for the treatment of non-small-cell lung cancer". Expert Review of Vaccines.
3. (8 September 2011). "Cuba Announces Release of the World's First Lung Cancer Vaccine". [[Popular Science]].
4. (23 April 2015). "Cuba has had a lung cancer vaccine for years". [[GlobalPost]].
5. (11 May 2015). "Cuba Has a Lung Cancer Vaccine—And America Wants It". [[Wired (website).
6. (8 September 2016). "Vacuna contra cáncer de pulmón llega al país". [[El Tiempo (Colombia)]].
7. (October 21, 2015). "Cuban anti-cancer vaccines soon to be available in Serbia".
8. (2020). "We Are Cuba! How a Revolutionary People Have Survived in a Post-Soviet World". [[Yale University Press]].
9. (12 May 2015). "Can you tell me about the CimaVax lung cancer vaccine?". [[Cancer Research UK]].
10. (October 2001). "Safety and preliminary immunogenicity of the recombinant outer membrane protein P64k of Neisseria meningitidis in human volunteers". Biotechnology and Applied Biochemistry.
11. (2010). "Clinical development and perspectives of CIMAvax EGF, Cuban vaccine for non-small-cell lung cancer therapy". MEDICC Review.
12. (March 2008). "Phase II randomized controlled trial of an epidermal growth factor vaccine in advanced non-small-cell lung cancer". Journal of Clinical Oncology.
13. (2017). "CIMAvax-EGF: A New Therapeutic Vaccine for Advanced Non-Small Cell Lung Cancer Patients". Frontiers in Immunology.
14. (19 April 2017). "Why an American went to Cuba for cancer care".
15. "CIMAvax Vaccine and Nivolumab in Treating Patients With Stage IIIB-IV Non-small Cell Lung Cancer - Full Text View - ClinicalTrials.gov".
16. (2 December 2016). "Cuba Has a Lung Cancer Vaccine; Now U.S. Patients Will Test It". KQED News.
17. (September 26, 2018). "Roswell Park Lung Cancer Expert Shares Initial Findings From First North American Study of CIMAvax". Roswell Park Comprehensive Cancer Center.
18. (March 30, 2019). "With Safety Analysis Now Complete, Roswell Park Moves Forward With Expanded Study of CIMAvax". Roswell Park Comprehensive Cancer Center.
19. (1 June 2023). "Phase 2 trial of epidermal growth factor (EGF) vaccine CIMAvax in combination with pembrolizumab in first line and maintenance setting in advanced non–small cell lung cancer patients.". Journal of Clinical Oncology.