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Chlorphenesin carbamate

Muscle relaxant drug

Muscle relaxant drug

| Drugs.com =

| elimination_half-life =

Chlorphenesin carbamate (Maolate, Musil) is a centrally acting muscle relaxant used to treat muscle pain and spasms. Chlorphenesin carbamate is no longer used for this purpose in most developed nations due to the availability of much safer spasmolytics such as benzodiazepines.

Other central effects include sedation, anxiolysis, and dizziness.

Chlorphenesin

A related chemical, chlorphenesin (C9H11ClO3) without the carbamate group, is used as a preservative in products such as cosmetics. It has antifungal and some antibacterial properties, and is classified as an antifungal for topical use by the WHO.

The major adverse effect from this preservative on skin is allergic contact sensitivity. Systemic intoxication from transdermal use has not been observed, although the FDA discourages its use as an ingredient in nipple cream for nursing mothers.

References

References

  1. (February 1987). "Antinociceptive effect of chlorphenesin carbamate in adjuvant arthritic rats". Research Communications in Chemical Pathology and Pharmacology.
  2. (September 1984). "Effect of a muscle relaxant, chlorphenesin carbamate, on the spinal neurons of rats". Japanese Journal of Pharmacology.
  3. [http://www.whocc.no/atc_ddd_index/?code=D01AE07 ATC code D01AE07]
  4. (May 1981). "Chlorphenesin sensitivity". Contact Dermatitis.
  5. (April 1986). "Allergic contact sensitivity to chlorphenesin". Contact Dermatitis.
  6. "FDA Warns Consumers Against Using Mommy's Bliss Nipple Cream Product can be harmful to nursing infants".
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