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Chloropyridine
Chloropyridines are a group of aryl chlorides consisting of a pyridine ring with chlorine atoms as substituents.
Chloropyridines include:
- 2-Chloropyridine
- 3-Chloropyridine
- 4-Chloropyridine (used for ofornine & besipirdine).
- 2,6-Dichloropyridine
Production
2- and 4-chloropyridine are prepared from the corresponding pyridinols using phosphoryl chloride.
Uses
Chloropyridines are important intermediates to pharmaceuticals and agrochemicals. A major use of 2-chloropyridine is the production of production of the fungicide pyrithione. Reaction of 4-chloropyridine with thioglycolic acid gives pyridylmercaptoacetic acid, a step in the production of cephalosporin antibiotics.
References
References
- (2000). "Pyridine and Pyridine Derivatives".
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