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Cethromycin

Chemical compound

Field	Value
Verifiedfields	changed
Watchedfields	changed
verifiedrevid	445236160
IUPAC_name	(1S,2R,5R,7R,8R,9S,11R,13R,14R)-8-[(2S,3R,4S,6R)- 4-Dimethylamino-3-hydroxy-6-methyloxan-2-yl]oxy-2-ethyl-1,5,7,9,11,13- hexamethyl-9-[(E)-3-quinolin-3-ylprop-2-enoxy] -3,17-dioxa-15-azabicyclo[12.3.0]heptadecane-4,6,12,16-tetrone
image	Cethromycin1.svg
image_class	skin-invert-image
pregnancy_AU
pregnancy_US
legal_AU
legal_CA
legal_UK
legal_US_comment	Phase III Clinical Trials
routes_of_administration	Oral
bioavailability	Between 35.8 and 60% in animal studies.
metabolism	Liver
elimination_half-life	1.6, 3.0, 4.5, 5.9 and 6 hours. Mouse, Monkey, Rat, Dog and Human respectively.
excretion	7.0% urine 87.2% faeces
CAS_number_Ref
CAS_number	205110-48-1
ATC_prefix	none
PubChem	5282045
ChEBI	29506
DrugBank_Ref
ChEMBL_Ref
ChEMBL	365528
UNII_Ref
UNII	J0086219X6
KEGG_Ref
KEGG	D02391	ChemSpiderID_Ref =
ChemSpiderID	23258189
smiles	CC[C@@H]1[C@@]2(C@@HNC(=O)O2)C
StdInChI_Ref
StdInChI	1S/C42H59N3O10/c1-11-32-42(8)36(44-40(50)55-42)25(4)33(46)23(2)21-41(7,51-18-14-15-28-20-29-16-12-13-17-30(29)43-22-28)37(26(5)34(47)27(6)38(49)53-32)54-39-35(48)31(45(9)10)19-24(3)52-39/h12-17,20,22-27,31-32,35-37,39,48H,11,18-19,21H2,1-10H3,(H,44,50)/b15-14+/t23-,24-,25+,26+,27-,31+,32-,35-,36-,37-,39+,41+,42-/m1/s1
StdInChIKey_Ref
StdInChIKey	PENDGIOBPJLVBT-HMMOOPTJSA-N
C	42	H=59	N=3	O=10
melting_point	211
melting_high	213

| elimination_half-life = 1.6, 3.0, 4.5, 5.9 and 6 hours. Mouse, Monkey, Rat, Dog and Human respectively.

Cethromycin, trade name Restanza (initially known as ABT-773{{cite journal |doi-access=free

On October 1, 2008, Advanced Life Sciences submitted a New Drug Application (NDA) to Food and Drug Administration (FDA) for cethromycin to treat mild-to-moderate community acquired pneumonia.

On December 3, 2008, Advanced Life Sciences announced that this New Drug Application has been accepted for filing by the FDA.

In June 2009, an FDA Anti-Infective Drugs Advisory Committee review found insufficient evidence for cethromycin efficacy in treatment of community acquired pneumonia, as the Phase 3 clinical trial followed standards that were updated after the clinical trial but three months prior to review. The committee did, however, find the drug safe to use.

References

link. (April 20, 2008)
[https://www.drugs.com/nda/cethromycin_081001.html Cethromycin New Drug Application]
(June 2019)
Advanced Life Sciences Holdings, Inc.. "Complete Response Letter for Restanza NDA". Drugs.com.

Info: Wikipedia Source

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