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Caspase 10

Enzyme found in humans

Enzyme found in humans

Caspase-10 is an enzyme that, in humans, is encoded by the CASP10 gene.

This gene encodes a protein that is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes that undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme.

That protein cleaves and activates caspases 3 and 7, and the protein itself is processed by caspase 8. Mutations in this gene are associated with apoptosis defects seen in type II autoimmune lymphoproliferative syndrome. Three alternatively spliced transcript variants encoding different isoforms have been described for this gene.

Interactions

Caspase 10 has been shown to interact with FADD, CFLAR, Caspase 8, Fas receptor, RYBP, TNFRSF1A and TNFRSF10B.

References

References

  1. (October 1996). "In vitro activation of CPP32 and Mch3 by Mch4, a novel human apoptotic cysteine protease containing two FADD-like domains". Proc Natl Acad Sci USA.
  2. "Entrez Gene: CASP10 caspase 10, apoptosis-related cysteine peptidase".
  3. Vincenz, C. (March 1997). "Fas-associated death domain protein interleukin-1beta-converting enzyme 2 (FLICE2), an ICE/Ced-3 homologue, is proximally involved in CD95- and p55-mediated death signaling". J. Biol. Chem..
  4. (July 1997). "FLAME-1, a novel FADD-like anti-apoptotic molecule that regulates Fas/TNFR1-induced apoptosis". J. Biol. Chem..
  5. Wang, J. (November 2001). "Caspase-10 is an initiator caspase in death receptor signaling". [[PNAS.
  6. Micheau, Olivier. (July 2003). "Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes". Cell.
  7. Goltsev, Y V. (August 1997). "CASH, a novel caspase homologue with death effector domains". J. Biol. Chem..
  8. Gajate, Consuelo. (March 2005). "Cytoskeleton-mediated death receptor and ligand concentration in lipid rafts forms apoptosis-promoting clusters in cancer chemotherapy". J. Biol. Chem..
  9. Guo, Yin. (April 2002). "Caspase-2 induces apoptosis by releasing proapoptotic proteins from mitochondria". J. Biol. Chem..
  10. Srinivasula, S M. (December 1996). "Molecular ordering of the Fas-apoptotic pathway: The Fas/APO-1 protease Mch5 is a CrmA-inhibitable protease that activates multiple Ced-3/ICE-like cysteine proteases". [[PNAS.
  11. MacFarlane, M. (October 1997). "Identification and molecular cloning of two novel receptors for the cytotoxic ligand TRAIL". J. Biol. Chem..
  12. Zheng, L. (August 2001). "The death effector domain-associated factor plays distinct regulatory roles in the nucleus and cytoplasm". J. Biol. Chem..
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