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Carboxylesterase type B

Family of evolutionarily related proteins

Family of evolutionarily related proteins

Carboxylesterase, type B is a family of evolutionarily related proteins that belongs to the superfamily of proteins with the Alpha/beta hydrolase fold.

Higher eukaryotes have many distinct esterases. The different types include those that act on carboxylic esters (). Carboxyl-esterases have been classified into three categories (A, B and C) on the basis of differential patterns of inhibition by organophosphates. The sequence of a number of type-B carboxylesterases indicates that the majority are evolutionarily related. As is the case for lipases and serine proteases, the catalytic apparatus of esterases involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.

Subfamilies

  • Neuroligin
  • Cholinesterase

Examples

Human genes that encode proteins containing the carboxylesterase domain include:

  • ACHE
  • ARACHE
  • BCHE
  • CEL
  • CES1
  • CES2
  • CES3
  • CES4
  • CES7
  • CES8
  • NLGN1
  • NLGN2
  • NLGN3
  • NLGN4X
  • NLGN4Y
  • TG

References

References

  1. (February 2005). "Role of water in aging of human butyrylcholinesterase inhibited by echothiophate: the crystal structure suggests two alternative mechanisms of aging". Biochemistry.
  2. (1988). "On the origins of esterases". Mol. Biol. Evol..
  3. (1991). "Cholinesterase-like domains in enzymes and structural proteins: functional and evolutionary relationships and identification of a catalytically essential aspartic acid". Proc. Natl. Acad. Sci. U.S.A..
  4. (1993). "Relationship between sequence conservation and three-dimensional structure in a large family of esterases, lipases, and related proteins". Protein Sci..
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