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Carbocisteine

Carbocisteine, also called carbocysteine, is a mucolytic that reduces the viscosity of sputum and so can be used to help relieve the symptoms of chronic obstructive pulmonary disorder (COPD) and bronchiectasis by allowing the sufferer to bring up sputum more easily. Carbocisteine should not be used with antitussives (cough suppressants) or medicines that dry up bronchial secretions.

It was first described in 1951 and came into medical use in 1960. Carbocisteine is produced by alkylation of cysteine with chloroacetic acid.

References

References

  1. [https://www.drugbank.ca/drugs/DB04339 Carbocisteine]. drugbank.ca
  2. (2008). "Effect of carbocisteine on acute exacerbation of chronic obstructive pulmonary disease (PEACE Study): A randomised placebo-controlled study". Lancet.
  3. (2006). "Carbocisteine reduces frequency of common colds and exacerbations in patients with chronic obstructive pulmonary disease". Journal of the American Geriatrics Society.
  4. (2006). "Analogue-based Drug Discovery". John Wiley & Sons.
  5. (2007). "Amino Acids".
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dicarboxylic-acids expectorants thioethers alpha-amino-acids amino-acid-derivatives
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