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Captopril challenge test

Non-invasive medical test

Field	Value
name	Captopril challenge test
image	Image:Captopril skeletal.svg
caption	Captopril chemical structure.
purpose	measures the change in renin plasma-levels
DiseasesDB
ICD10
MedlinePlus
eMedicine
OPS301
LOINC

NOTOC The captopril challenge test (CCT) is a non-invasive medical test that measures the change in renin plasma-levels in response to administration of captopril, an angiotensin converting enzyme inhibitor. It is used to assist in the diagnosis of renal artery stenosis. It is not generally considered a useful test for children, and more suitable options are available for adult cases.

Procedure

Plasma concentration of renin is measured prior to and following the administration of captopril. The CCT is considered positive if the renin levels increase substantially or the baseline renin level is abnormally high.

In adults

CCT in adults is known to have high sensitivity, but a low specificity.

Subtraction angiography is considered a more suitable test for renal artery stenosis in adults.

References

Gauthier, B.. (1991). "Inadequacy of captopril challenge test for diagnosing renovascular hypertension in children and adolescents". Pediatric Nephrology.
Muller, F. B.. (1986). "The captopril test for identifying renovascular disease in hypertensive patients". The American Journal of Medicine.
Bales, A.. (1999-05-01). "Hypertensive crisis. How to tell if it's an emergency or an urgency". Postgraduate Medicine.
Svetkey, L. P.. (1989). "Prospective analysis of strategies for diagnosing renovascular hypertension". Hypertension.

Info: Wikipedia Source

This article was imported from Wikipedia and is available under the Creative Commons Attribution-ShareAlike 4.0 License. Content has been adapted to SurfDoc format. Original contributors can be found on the article history page.

blood-tests dynamic-endocrine-function-tests

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