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Calphostin

Class of fungi

Class of fungi

The calphostins are a class of closely related chemical compounds isolated from the fungus Cladosporium cladosporioides. The known calphostins include calphostin A, calphostin B, calphostin C, calphostin D, and calphostin I. The calphostins are inhibitors of protein kinase C (PKC). The most potent member of the series, calphostin C, has found use as a biochemical tool because of this activity.

Calphostin I4-(HO)Bz4-(HO)Bz

Calphostin C

Main article: Calphostin C

Calphostin C is a potent inhibitor of protein kinase C (PKC).

References

References

  1. (1989). "Calphostins (UCN-1028), novel and specific inhibitors of protein kinase C. I. Fermentation, isolation, physico-chemical properties and biological activities". Journal of Antibiotics.
  2. (1989). "Calphostins, novel and specific inhibitors of protein kinase C. II. Chemical structures". Journal of Antibiotics.
  3. "Calphostin C". Biomol GmbH.
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o-methylated-natural-phenols cladosporium 3-hydroxypropenals-within-hydroxyquinones
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