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Calcium-binding EGF domain

FieldValue
SymbolEGF_CA
NameCalcium-binding EGF domain
imagePDB 1szb EBI.jpg
captioncrystal structure of the human mbl-associated protein 19 (map19)
PfamPF07645
Pfam_clanCL0001
InterProIPR013091
CDDcd00054

In molecular biology, the calcium-binding EGF domain is an EGF-like domain of about forty amino-acid residues found in epidermal growth factor (EGF). This domain is present in a large number of membrane-bound and extracellular, mostly animal, proteins. Many of these proteins require calcium for their biological function and a calcium-binding site has been found at the N-terminus of some EGF-like domains. Calcium-binding may be crucial for numerous protein-protein interactions.

For human coagulation factor IX it has been shown that the calcium-ligands form a pentagonal bipyramid. The first, third and fourth conserved negatively charged or polar residues are side chain ligands. The latter is possibly hydroxylated. A conserved aromatic residue, as well as the second conserved negative residue, are thought to be involved in stabilising the calcium-binding site.

As in non-calcium binding EGF-like domains, there are six conserved cysteines and the structure of both types is very similar as calcium-binding induces only strictly local structural changes.

References

References

  1. Davis CG. (May 1990). "The many faces of epidermal growth factor repeats". New Biol..
  2. (December 1984). "Vaccinia virus 19-kilodalton protein: relationship to several mammalian proteins, including two growth factors". Proc. Natl. Acad. Sci. U.S.A..
  3. (June 1986). "[Similar domains in different proteins: detection and significance]". Tanpakushitsu Kakusan Koso.
  4. (1984). "Computer-based characterization of epidermal growth factor precursor". Nature.
  5. (April 1988). "Structure and function of epidermal growth factor-like regions in proteins". FEBS Lett..
  6. (September 1992). "How an epidermal growth factor (EGF)-like domain binds calcium. High resolution NMR structure of the calcium form of the NH2-terminal EGF-like domain in coagulation factor X". J. Biol. Chem..
  7. (July 1995). "The structure of a Ca(2+)-binding epidermal growth factor-like domain: its role in protein-protein interactions". Cell.
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