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Calcium-activated potassium channel beta subunit

Field	Value
Symbol	CaKB
Name	CaKB
image	PDB 1jo6 EBI.jpg
caption	solution structure of the cytoplasmic n-terminus of the bk beta-subunit kcnmb2
Pfam	PF03185
InterPro	IPR003930
SCOP	1jo6
TCDB	8.A.14

In molecular biology, the calcium-activated potassium channel beta subunit is a family of proteins comprising the beta subunits of calcium-activated potassium channels.

The functional diversity of potassium channels can arise through homo- or hetero-associations of alpha subunits or association with auxiliary cytoplasmic beta subunits. The beta subunit (which is thought to possess 2 transmembrane domains) increases the calcium sensitivity of the BK channel. It does this by enhancing the time spent by the channel in burst-like open states. However, it has little effect on the durations of closed intervals between bursts, or on the numbers of open and closed states entered during gating.

References

(March 1995). "Functional role of the beta subunit of high conductance calcium-activated potassium channels". Neuron.
(March 1999). "The beta subunit increases the Ca2+ sensitivity of large conductance Ca2+-activated potassium channels by retaining the gating in the bursting states". J. Gen. Physiol..

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