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Calcipressin

Family of proteins

Family of proteins

FieldValue
SymbolCalcipressin
NameCalcipressin
imagePDB 1wey EBI.jpg
captionsolution structure of rrm domain in calcipressin 1
PfamPF04847
Pfam_clanCL0221
InterProIPR006931

In molecular biology, the calcipressin family of proteins negatively regulate calcineurin by direct binding. They are essential for the survival of T helper type 1 cells. Calcipressin 1 is a phosphoprotein that increases its capacity to inhibit calcineurin when phosphorylated at the conserved FLISPP motif; this phosphorylation also controls the half-life of calcipressin 1 by accelerating its degradation.

In humans, the Calcipressins family of proteins is derived from three genes:

  • Calcipressin 1 (encoded by RCAN1) is also known as modulatory calcineurin-interacting protein 1 (MCIP1), Adapt78 and Down syndrome critical region 1 (DSCR1).
  • Calcipressin 2 (encoded by RCAN2) is variously known as MCIP2, ZAKI-4 and DSCR1-like 1.
  • Calcipressin 3 (encoded by RCAN3) is also called MCIP3 and DSCR1-like 2.

References

References

  1. (September 2003). "Phosphorylation of calcipressin 1 increases its ability to inhibit calcineurin and decreases calcipressin half-life". Biochem. J..
  2. (September 2003). "Calcium-independent calcineurin regulation". Nat. Immunol..
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