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Bromhexine

Mucolytic drug

Mucolytic drug

| Drugs.com =

| elimination_half-life = 12 hr

Bromhexine, sold under the brand name Bisolvon among others, is a mucolytic drug used in the treatment of respiratory disorders associated with viscid or excessive mucus. It was developed in the research laboratory of Boehringer Ingelheim in the late 1950s as an active ingredient for pharmaceutical use, patented in 1961, introduced in 1963 under the trademark of Bisolvon® and came into medical use in 1966.

Function

Bromhexine is intended to support the body's mechanisms for clearing mucus from the respiratory tract. It is secretolytic, increasing the production of serous mucus in the respiratory tract, which makes the phlegm thinner and less viscous. This contributes to a secretomotoric effect, allowing the cilia to more easily transport the phlegm out of the lungs. For this reason it is often added to cough syrups.

It has been shown to increase the proportion of serous bronchial secretion, making it more easily expectorated. It is indicated as "secretolytic therapy in bronchopulmonary diseases associated with abnormal mucus secretion and impaired mucus transport".

Bromhexine is contained in various formulations, high and low strength syrups 8 mg/5 ml, 4 mg/5 ml, tablets and soluble tablets (both with 8 mg bromhexine) and solution for oral use 10 mg/5 ml, adapted to the need of the patients. The posology varies with the age and weight, but there are products for all age groups from infant on. Bromhexine is well established and tolerated.

Brand names

  • Barkacin
  • Benadryl Chesty/Forte
  • Bisolvon
  • Brofentol
  • Brofentol Plus
  • Bromex
  • Bromhexin
  • Bromifar
  • Broncholyte Elixir
  • Bronkris
  • Cofdex
  • Duro-Tuss Chesty/Forte
  • Dysolvon
  • Flegamina
  • Movex
  • Mucohexin
  • Mucolyte
  • Paxirasol
  • Robitussin Chesty/Forte
  • Solvex
  • Vasican
  • Ventilate Forte (combination of bromhexine and salbutamol)

References

References

  1. (May 2025). "Therapeutic Goods (Poisons Standard— June 2025) Instrument 2025".
  2. (1999). "Concise Dictionary of Pharmacological Agents". Springer.
  3. (2006). "Analogue-based Drug Discovery". John Wiley & Sons.
Info: Wikipedia Source

This article was imported from Wikipedia and is available under the Creative Commons Attribution-ShareAlike 4.0 License. Content has been adapted to SurfDoc format. Original contributors can be found on the article history page.

antidotes expectorants anilines bromobenzene-derivatives cyclohexyl-compounds
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