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BNR/Asp-box repeat

Field	Value
Symbol	BNR
Name	BNR/Asp-box repeat
image	PDB 1euu EBI.jpg
caption	Structure of a bacterial sialidase.
Pfam	PF02012
Pfam_clan	CL0434
InterPro	IPR002860
SCOP	1euu

BNR/Asp-box repeat is a repetitive sequence of amino acids contained in some proteins. Many of these proteins contain multiple BNR (bacterial neuraminidase repeat) repeats or Asp-boxes.

The repeats are short, however the repeats are never found closer than 40 residues together suggesting that the repeat is structurally longer. The Asp-box itself adopts a well-defined beta-hairpin fold. These repeats are found in a variety of non-homologous proteins, including bacterial ribonucleases, sulphite oxidases, reelin, netrins, sialidases, neuraminidases, some lipoprotein receptors, and a variety of glycosyl hydrolases.

Examples

Human genes encoding proteins containing this domain include:

NEU1
NEU2
NEU3
RELN
SORCS1
SORCS2
SORCS3
SORL1
SORT1

References

(November 1995). "The three domains of a bacterial sialidase: a beta-propeller, an immunoglobulin module and a galactose-binding jelly-roll". Structure.
(November 1993). "Crystal structure of a bacterial sialidase (from Salmonella typhimurium LT2) shows the same fold as an influenza virus neuraminidase". Proceedings of the National Academy of Sciences of the United States of America.
(July 2009). "Sequence and structural analysis of the Asp-box motif and Asp-box beta-propellers; a widespread propeller-type characteristic of the Vps10 domain family and several glycoside hydrolase families". BMC Structural Biology.
(February 2001). "Sialidase-like Asp-boxes: sequence-similar structures within different protein folds". Protein Science.

Info: Wikipedia Source

This article was imported from Wikipedia and is available under the Creative Commons Attribution-ShareAlike 4.0 License. Content has been adapted to SurfDoc format. Original contributors can be found on the article history page.

protein-structural-motifs

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