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Bisulepin

Chemical compound

Chemical compound

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Bisulepin is strong and relatively selective antihistamine (H1 antagonist) with hypnotic, antiadrenergic and very weak anticholinergic and antiserotonergic effects. Bisulepin is marketed in the Czech Republic and Slovakia under the trademark Dithiaden as tablets and injections.

The registered active form is the trans- (i.e. E-) isomer.

References

References

  1. (1983). "Antiaminic agents derived from thieno[2,3-c]-2-benzothiepin: 4-(1-Methyl-4-piperidylidene)-4,9-dihydrothieno[2,3-c]-2-benzothiepin and some related compounds". Collection of Czechoslovak Chemical Communications.
  2. Pharmacopoea Bohemoslovenica 4 (1987), vol. 2, p. 132 states that Bisulepinium chloratum (bisulepinium chloride) is ''trans''-[3-(4,9-dihydro-thieno[2,3-''c''][2]benzithiepin-4-yliden)propyl]dimethylamoniumchlorid (Czech). The ''cis''- isomer is considered as an impurity, max. amount 2.0 %.
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h1-receptor-antagonists thiepines thiophenes antihistamines
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