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Biphenyl-2,3-diol 1,2-dioxygenase

Field	Value
Name	biphenyl-2,3-diol 1,2-dioxygenase
EC_number	1.13.11.39
CAS_number	103679-58-9
GO_code	0018583
image	2ZI8.png
caption	Crystallographic structure of the HsaC extradiol dioxygenase from M. tuberculosis (rainbow colored, N-terminus = blue, C-terminus = red) complexed with 3,4-DHSA (space-filling model (carbon = white, oxygen = red).

Biphenyl-2,3-diol 1,2-dioxygenase () is an enzyme that catalyzes the chemical reaction

:biphenyl-2,3-diol + O2 \rightleftharpoons 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate + H2O

Thus, the two substrates of this enzyme are biphenyl-2,3-diol and oxygen, whereas its two products are 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate and water.

This enzyme belongs to the family of oxidoreductases, specifically those acting on single donors with O2 as oxidant and incorporation of two atoms of oxygen into the substrate (oxygenases). The oxygen incorporated need not be derived from O2. The systematic name of this enzyme class is biphenyl-2,3-diol:oxygen 1,2-oxidoreductase (decyclizing). Other names in common use include 2,3-dihydroxybiphenyl dioxygenase, and biphenyl-2,3-diol dioxygenase. This enzyme participates in gamma-hexachlorocyclohexane degradation and biphenyl degradation.

Structural studies

As of late 2007, 16 structures have been solved for this class of enzymes, with PDB accession codes , , , , , , , , , , , , , , , and .

References

(March 2009). "Studies of a Ring-Cleaving Dioxygenase Illuminate the Role of Cholesterol Metabolism in the Pathogenesis of Mycobacterium tuberculosis". PLOS Pathog..

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ec-1.13.11 enzymes-of-known-structure

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