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Beta hydroxycarboxylic acid

Class of chemical compounds

A beta hydroxy carboxylic acid or β-hydroxy carboxylic acid (BHA) is a carboxylic acid containing a hydroxy functional group separated by two carbon atoms. They are related to alpha hydroxy acids, in which the two functional groups are separated by only one carbon atom.

Reactions

Upon dehydration, beta-hydroxy acids yield an alpha-beta unsaturated acid.

Compared to their non-hydroxylated counterpart, beta hydroxy carboxylic acids are stronger, although weaker than the alpha hydroxy acids. Due to the larger distance, the intramolecular hydrogen bridge is less easily formed compared to the alpha hydroxy acids. The table summarizes some values on the propionic series.

Name	pKa
Propanoic acid	4.87
α-Hydroxypropionic acid	3.86
β-Hydroxypropionic acid	4.51

Occurrence and inventory

Aldonic acids, a type of sugar acid, are a class of naturally occurring β-hydroxycarboxylic acids. They have the general chemical formula HO2C(CHOH)nCH2OH. Gluconic acid, a particularly common aldonic acid, the oxidized derivative of glucose.

Other beta hydroxy acids include:

β-Hydroxybutyric acid
3-Hydroxypentanoic acid
3-Hydroxyoctanoic acid
3-Hydroxydecanoic acid
β-Hydroxy β-methylbutyric acid
Carnitine
Salicylic acid, a β-hydroxy acid. In cosmetics, the term beta hydroxy acid refers specifically to salicylic acid, which is used in some "anti-aging" creams and acne treatments. It is used to combat inflammation.

References

ar:حمض هيدروكسي

References

(2000). "Hydroxycarboxylic Acids, Aliphatic".
Handbook of Chemistry and Physics, CRC press, 58th edition page D150-151 (1977)
Dawson, R. M. C. ''et al''., ''Data for Biochemical Research'', Oxford, Clarendon Press, 1959.

Info: Wikipedia Source

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beta-hydroxycarboxylic-acids

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