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Benexate

Chemical compound

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Benexate (BEX) is an anti-ulcer agent used in the treatment of acid-related disorders. It is unique in its inability to form salts that are both non-bitter and soluble.

Medical uses

Benexate is approved from treatment of gastric ulcer in Japan.

Mechanism of action

The mechanism of action of benexate involves promotion of prostaglandin synthesis, protein secretion, and blood flow stimulation in the gastrointestinal tract.

References

(1996). "Differential effect of benexate hydrochloride betadex on prostaglandin levels in stomach and inflammatory sites in rats". Japanese Journal of Pharmacology.
(1998). "Studies of benexate CD: effect of inclusion compound formation on the antiulcer activity of benexate, the effective ingredient of benexate CD.". Folia Pharmacologica Japonica.
"Benexate". National Center for Advancing Translational Sciences.
(2016). "Benexate hydrochloride betadex modulates nitric oxide synthesis and cytokine expression in gastric ulcers". Experimental and Therapeutic Medicine.

Info: Wikipedia Source

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drugs-acting-on-the-gastrointestinal-system-and-metabolism guanidines salicylate-esters salicylyl-esters cyclohexanes

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