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Bemegride
Chemical compound
Chemical compound
| Drugs.com = β,β-methylethylglutarimide
Bemegride, sold under the brand name Megimide among others, is a central nervous system (CNS) stimulant first manufactured in 1911, and which has been used in hypnotic overdose.
As with other chemoreceptor agonists, it is a potent emetic at doses above those normally used in management of barbiturate overdose, although vomiting and aspiration are a concern during treatment. It is a controlled substance in some countries,
Synthesis
The original synthesis involves first the condensation of methylethylketone with two equivalents of cyanoacetamide. The product can be rationalized by assuming first aldol condensation of ketone and active methylene compound followed by dehydration to give 3. Conjugate addition of a second molecule of cyanoacetamide would afford 4. Addition of one of the amide amines to the nitrile would then afford the iminonitrile 5. The observed product 6 can be rationalized by assuming loss of the carboxamide under strongly basic conditions. Decarboxylative hydrolysis of 6 then leads to bemegride 7.
Society and culture
John Bodkin Adams case
Bemegride was the drug which suspected serial killer John Bodkin Adams who, as a general practitioner, failed to prescribe correctly to his patient Gertrude Hullett. Hullett took an overdose of barbiturates on 19 July 1956, but Adams only gave her a single 10cc dose of bemegride three days later on the 22nd, despite having acquired 100cc for her treatment. Hullett died the next day on 23 July 1956. Adams was charged but never tried for her murder.
References
References
- (2000). "Analeptics". Ullmann's Encyclopedia of Industrial Chemistry.
- (1911). "LIII.—The formation and reactions of iminocompounds. Part XV. The production of imino-derivatives of piperidine leading to the formation of the ββ-disubstituted glutaric acids". Journal of the Chemical Society, Transactions.
- and is sometimes used to induce [[convulsion]]s in experimental animals.[http://cancerweb.ncl.ac.uk/cgi-bin/omd?bemegride Definition: bemegride from Online Medical Dictionary]
- Cullen, Pamela V., ''A Stranger in Blood: The Case Files on Dr John Bodkin Adams'', London, Elliott & Thompson, 2006, {{ISBN. 1-904027-19-9
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