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Bay R 1531

Chemical compound

Chemical compound

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Bay R 1531, also known as LY-197206 or as 4,α-methylene-5-MeO-DPT, is a tricyclic tryptamine derivative. It acts as a selective serotonin 5-HT1A receptor agonist. It was investigated unsuccessfully for the treatment of stroke but continues to be used in scientific research. It shows very high affinity for the serotonin 5-HT1A receptor (Ki = 1.3nM).

References

References

  1. (December 1990). "5-hydroxytryptamine1A agonists. A new therapeutic principle for stroke treatment". Stroke.
  2. (1992). "Actions and some interactions of 5-HT1A ligands in the elevated X-maze and effects of dorsal raphe lesions". Psychopharmacology.
  3. (March 1997). "High intensity social conflict in the Swiss albino mouse induces analgesia modulated by 5-HT1A receptors". Pharmacology, Biochemistry, and Behavior.
  4. (March 1998). "Involvement of the midbrain periaqueductal gray 5-HT1A receptors in social conflict induced analgesia in mice". European Journal of Pharmacology.
  5. (December 1991). "Structure-activity relationships at 5-HT1A receptors: binding profiles and intrinsic activity". Pharmacol Biochem Behav.
  6. (October 1987). "Relative selectivity of some conformationally constrained tryptamine analogs at 5-HT1, 5-HT1A and 5-HT2 recognition sites". Life Sci.
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alpha-alkyltryptamines n,n-dialkyltryptamines heterocyclic-compounds-with-3-rings 5-methoxytryptamines partial-ergolines serotonin-receptor-agonists
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