B56 domain

Function

Protein phosphatase 2A (PP2A) is a major intracellular protein phosphatase that regulates multiple aspects of cell growth and metabolism such as DNA replication, transcription, translation, cell cycle, development, and apoptosis.

In order to exhibit specificity control over catalysis, hetero-oligomers are formed so the catalytic subunits are complexed with regulatory subunits. This helps direct their action towards the cellular substrate. This is the function of the B56 domain.

B56 alpha, is additionally thought to play a role in nuclear export.

Structure

Regulatory B subunit is a heterotrimer.

Subcellular Localization

Mainly found in the cytoplasm, however various isoforms can be found in the nucleus.

Isoforms of B56 protein family

• B56alpha
• B56beta
• B56delta
• B56epsilon
• B56gamma

References

References

1. (November 1995). "Identification of a new family of protein phosphatase 2A regulatory subunits". J. Biol. Chem..
2. (2009). "The structure of the PP2A regulatory subunit B56 gamma: the remaining piece of the PP2A jigsaw puzzle.". Proteins.
3. (2010). "Nuclear export and centrosome targeting of the protein phosphatase 2A subunit B56alpha: role of B56alpha in nuclear export of the catalytic subunit.". J Biol Chem.