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Arotinolol

Chemical compound

Chemical compound

| Drugs.com =

| elimination_half-life = 10 hours

Arotinolol (INN, marketed under the tradename Almarl) is a medication in the class of mixed alpha/beta blockers. It also acts as a β3 receptor agonist. A 1979 publication suggests arotinolol as having first been described in the scientific literature by Sumitomo Chemical as "β-adrenergic blocking, antiarrhythmic compound S-596".

Medical uses

It is used in the treatment of high blood pressure and essential tremor. Recommended dosage is 10 to 30 mg per day.

References

References

  1. (July 2001). "Arotinolol is a weak partial agonist on beta 3-adrenergic receptors in brown adipocytes". Canadian Journal of Physiology and Pharmacology.
  2. (September 1992). "Beta-3 adrenergic agonist, BRL-26830A, and alpha/beta blocker, arotinolol, markedly increase regional blood flow in the brown adipose tissue in anesthetized rats". Japanese Circulation Journal.
  3. (1979). "新しいβ-受容体遮断薬，dl-2-(3'-t-Butylamino-2'-hydroxypropylthio)-4-(5'-carbamoyl-2'-thienyl)-thiazole hydrochloride (S-596) の薬理作用". Folia Pharmacologica Japonica.
  4. (September 2001). "Clinical trial of arotinolol in the treatment of hypertension: dippers vs. non-dippers". Hypertension Research.
  5. (August 2003). "A multicenter randomized crossover multiple-dose comparison study of arotinolol and propranolol in essential tremor". Parkinsonism & Related Disorders.
  6. "Almarl (アルマール) Arotinolol HCl Tablets. Full Prescribing Information". Sumitomo Dainippon Pharma Co., Ltd..
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alpha-1-blockers secondary-amines beta-blockers beta3-adrenergic-agonists carboxamides secondary-alcohols tert-butyl-compounds thiazoles thioethers thiophenes
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