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ARF6

Protein-coding gene in the species Homo sapiens

Protein-coding gene in the species Homo sapiens

ADP-ribosylation factor 6 (ARF6) is a member of the ADP ribosylation factor family of GTP-binding proteins. ARF6 has a variety of cellular functions that are frequently involved in trafficking of biological membranes and transmembrane protein cargo. ARF6 has specifically been implicated in endocytosis of plasma membrane proteins and also, to a lesser extent, plasma membrane protein recycling.

Function

This gene encodes a member of the human ARF gene family, which is part of the Ras superfamily. The ARF genes encode small guanine nucleotide-binding proteins that stimulate the ADP-ribosyltransferase activity of cholera toxin and play a role in vesicular trafficking and as activators of phospholipase D. The product of this gene is localized to the plasma membrane, and regulates vesicular trafficking, remodelling of membrane lipids, and signaling pathways that lead to actin remodeling. A pseudogene of this gene is located on chromosome 7.

ARF6 can interact with βarrestin upon receptor activation.

Interactions

ARF6 has been shown to interact with:

  • ARRB1
  • ARFIP2
  • CHRM3
  • EXOC5
  • KIAA0090
  • Rac1

References

References

  1. "Entrez Gene: ARF6 ADP-ribosylation factor 6".
  2. (November 2001). "beta-Arrestin-mediated ADP-ribosylation factor 6 activation and beta 2-adrenergic receptor endocytosis". J. Biol. Chem..
  3. (September 1997). "A role for POR1, a Rac1-interacting protein, in ARF6-mediated cytoskeletal rearrangements". EMBO J..
  4. (August 2001). "Differential binding of arfaptin 2/POR1 to ADP-ribosylation factors and Rac1". Biochem. Biophys. Res. Commun..
  5. (September 2003). "ADP-ribosylation factor-dependent phospholipase D activation by the M3 muscarinic receptor". J. Biol. Chem..
  6. (December 2003). "ARF6 controls post-endocytic recycling through its downstream exocyst complex effector". J. Cell Biol..
  7. (July 2006). "APID: Agile Protein Interaction DataAnalyzer". Nucleic Acids Res..
  8. (December 2012). "Adult neuronal Arf6 controls ethanol-induced behavior with Arfaptin downstream of Rac1 and RhoGAP18B". J. Neurosci..
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