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Archaeosine synthase

Enzyme

Field	Value
Name	Archaeosine synthase
EC_number	2.6.1.97

Archaeosine synthase (, ArcS, TgtA2, MJ1022 (gene), glutamine:preQ0-tRNA amidinotransferase) is an enzyme with systematic name L-glutamine:7-cyano-7-carbaguanine aminotransferase. This enzyme catalyses the following chemical reaction

: L-glutamine + 7-cyano-7-carbaguanine15 in tRNA + H2O \rightleftharpoons L-glutamate + archaeine15 in tRNA

In Euryarchaeota the reaction is catalysed by ArcS.

References

(April 2010). "Discovery and characterization of an amidinotransferase involved in the modification of archaeal tRNA". The Journal of Biological Chemistry.
(February 2012). "Diversity of archaeosine synthesis in crenarchaeota". ACS Chemical Biology.

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ec-2.6.1

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