From Surf Wiki (app.surf) — the open knowledge base

Aminoshikimate pathway

The Aminoshikimate pathway is a biochemical pathway present in some plants, which has been studied by biologists, biochemists and especially those interested in manufacture of novel antibiotic drugs. The pathway is a novel variation of the shikimate pathway. The aminoshikimate pathway was first discovered and studied in the rifamycin B producer Amycolatopsis mediterranei. Its end product, 3-amino-5-hydroxybenzoate, serves as an initiator for polyketide synthases in the biosynthesis of ansamycins.{{cite journal| author= Floss, H. G. | url-access = subscription

Overview

Floss and coworkers identified the gene cluster associated with the aminoshikimate pathway in Amycolatopsis mediterranei.{{cite journal|author1=August, P. R. |author2=tang, L. |author3=Yoon, Y. J. |author4=Ning, S. |author5=Muller, R. |author6=Yu, T. -W. |author7=Taylor, M. |author8=Hoffmann, D. |author9=Kim, C. -G. |author10=Zhang, X. |author11=Hutchinson, C. R. |author12=Floss, H. G.. | title = Biosynthesis of the ansamycin antibiotic rifamycin: deductions from the molecular analysis of the rif biosynthetic gene cluster of Amycolatopsis mediterranei S699 |doi-access=free }} The enzyme-catalyzed condensation of 1-deoxy-1-imino-D-erythrose 4-phosphate with phosphoenolpyruvate to form 4-amino-3,4-dideoxy-d-arabino-heptulosonic acid 7-phosphate has been proposed to be the first committed step in the aminoshikimate pathway. Guo and Frost demonstrated that the unusual metabolite, 1-deoxy-1-imino-D-erythrose 4-phosphate, is derived from 3-amino-3-deoxy-D-fructose 6-phosphate.{{cite journal|author1=Guo, Jiantao |author2=Frost, John | title = Biosynthesis of 1-Deoxy-1-imino-d-erythrose 4-Phosphate: A Defining Metabolite in the Aminoshikimate Pathway

Uses

Aminoshikimate pathway has been assembled in E. coli to synthesize aminoshikimic acid, which is a promising starting material for the synthesis of anti-influenza agent oseltamivir (brand name Tamiflu).{{cite journal|author1=Guo, Jiantao |author2=Frost, John | title = Synthesis of Aminoshikimic Acid

References

Frost, John W.; Guo, Jiantao {{patent. US. 2007190621A1. "Synthesis of oseltamivir carboxylates"

Info: Wikipedia Source

This article was imported from Wikipedia and is available under the Creative Commons Attribution-ShareAlike 4.0 License. Content has been adapted to SurfDoc format. Original contributors can be found on the article history page.

metabolic-pathways

Want to explore this topic further?

Ask Mako anything about Aminoshikimate pathway — get instant answers, deeper analysis, and related topics.

Research with Mako

Free with your Surf account

Content sourced from Wikipedia, available under CC BY-SA 4.0.

This content may have been generated or modified by AI. CloudSurf Software LLC is not responsible for the accuracy, completeness, or reliability of AI-generated content. Always verify important information from primary sources.

Report