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Alternative-complement-pathway C3/C5 convertase

FieldValue
NameAlternative-complement-pathway C3/C5 convertase
EC_number3.4.21.47
CAS_number80295-67-6

Alternative-complement-pathway C3/C5 convertase (, complement component C3/C5 convertase (alternative), proenzyme factor B, properdin factor B, C3 proactivator, glycine-rich beta-glycoprotein, heat-labile factor, C3 convertase, C3b,Bb,CVF,Bb,C5 convertase, (C3b)n,Bb, complement C 3(C 5) convertase (amplification), alternative complement pathway C3(C5) convertase, C5 convertase, CVF,Bb, (CVF)-dependent glycine-rich-beta-glucoprotein, cobra venom factor-dependent C3 convertase) is an enzyme. This enzyme catalyses the following chemical reaction

: Cleavage of Arg-Ser bond in complement component C3 alpha-chain to yield C3a and C3b, and Arg- bond in complement component C5 alpha-chain to yield C5a and C5b

This enzyme is a bimolecular complex of complement fragment Bb with either C3b or cobra venom factor.

References

References

  1. (1981). "Human factor B".
  2. (January 1984). "Internal homologies of the Ba fragment from human complement component Factor B, a class III MHC antigen". The EMBO Journal.
  3. (1988). "Molecular organization and function of the complement system". Annual Review of Biochemistry.
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