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Alpha/beta hydrolase superfamily

Field	Value
Symbol	Abhydrolase_1
image	1qge_opm.png
width	250
caption	A bacterial lipase, one of this family members
Pfam	PF00561
Pfam_clan	CL0028
ECOD	7579.1.1
InterPro	IPR029058
SCOP	1ede
OPM family	127
OPM protein	1qge
CDD	cl21494
Membranome superfamily	300

The alpha/beta hydrolase superfamily is a superfamily of hydrolytic enzymes of widely differing phylogenetic origin and catalytic function that share a common fold. The core of each enzyme is an alpha/beta-sheet (rather than a barrel), containing 8 beta strands connected by 6 alpha helices. The enzymes are believed to have diverged from a common ancestor, retaining little obvious sequence similarity, but preserving the arrangement of the catalytic residues. All have a catalytic triad, the elements of which are borne on loops, which are the best-conserved structural features of the fold.

The alpha/beta hydrolase fold includes proteases, lipases, peroxidases, esterases, epoxide hydrolases and dehalogenases.

Database

The ESTHER database provides a large collection of information about this superfamily of proteins.

Subfamilies

3-oxoadipate enol-lactonase

Human proteins containing this domain

ABHD10; ABHD11; ABHD12; ABHD12B; ABHD13; ABHD2; ABHD3; ABHD4; ABHD5; ABHD6; ABHD7; ABHD8; ABHD9; BAT5; BPHL; C20orf135; EPHX1; EPHX2; FAM108B1; LIPA; LIPF; LIPJ; LIPK; LIPM; LIPN; LYPLAL1; MEST; MGLL; PPME1; SERHL; SERHL2; SPG21; CES1; CES2; C4orf29

References

Ollis, D. L.. (1992). "The alpha/beta hydrolase fold". Protein Eng..
(2009). "Alpha/beta hydrolase fold: an update". Protein Pept. Lett..
(December 1999). "Alpha/beta hydrolase fold enzymes: the family keeps growing". Curr. Opin. Struct. Biol..
(December 2005). "New friendly tools for users of ESTHER, the database of the alpha/beta-hydrolase fold superfamily of proteins". Chem. Biol. Interact..

Info: Wikipedia Source

This article was imported from Wikipedia and is available under the Creative Commons Attribution-ShareAlike 4.0 License. Content has been adapted to SurfDoc format. Original contributors can be found on the article history page.

protein-domains peripheral-membrane-proteins hydrolases protein-superfamilies

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