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Allotopic expression
Type of gene expression
Type of gene expression
References
- de Grey AD. (September 2000). "Mitochondrial gene therapy: an arena for the biomedical use of inteins". Trends Biotechnol..
- (October 2003). "Limitations of allotopic expression of mitochondrial genes in mammalian cells". Genetics.
- Perales-Clemente, Ester. (Jan 2011). "Allotopic expression of mitochondrial-encoded genes in mammals: achieved goal, undemonstrated mechanism or impossible task?". Nucleic Acids Res..
- (February 2016). "Evolutionary Inference across Eukaryotes Identifies Specific Pressures Favoring Mitochondrial Gene Retention". Cell Systems.
- (2019). "Immune Response and Intraocular Inflammation in Patients With Leber Hereditary Optic Neuropathy Treated With Intravitreal Injection of Recombinant Adeno-Associated Virus 2 Carrying the ND4 Gene: A Secondary Analysis of a Phase 1/2 Clinical Trial". JAMA Ophthalmology.
- (27 December 2016). "Results from the Gensight Biologics Trial of ND4 Allotopic Expression".
- (2020). "Bilateral visual improvement with unilateral gene therapy injection for Leber hereditary optic neuropathy". Science Translational Medicine.
- "Gene Therapy Trial Successfully Improves Vision Mitochondrial gene therapy restores vision in landmark human trial".
- (10 December 2020). "Gene therapy injection in one eye surprises scientists by improving vision in both".
- [https://www.gensight-biologics.com/diseases-we-target/ Diseases We Target]
- (18 August 2016). "MitoSENS Project Results to be Published in the journal Nucleic Acids Research!". lifespan.io.
- "Stable nuclear expression of ATP8 and ATP6 genes rescues a mtDNA Complex V null mutant". Oxford Journals.
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