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Alkyl-lysophospholipids

Class of chemical compounds

Alky-lysophospholipids (ALPs) are synthetic analogs of lysophosphatidylcholines (LPCs), also called lysolecithins. They are synthesized by replacing the acyl-group within the LPC with an alkyl group. In contrast to LPCs, ALPs are metabolically very stable.

ALPs are being studied for their potential antineoplastic (anti-cancer) It is highly selective, sparing healthy cells. Several examples including edelfosine, miltefosine, and perifosine are under development as drugs against cancer and other diseases.

References

Munder, PG. (1979). "Lysophosphatidylcholine (Lysolecithin) and its Synthetic Analogues. Immunemodulating and Other Biologic Effects". Springer Seminars in Immunopathology.
Houlihan, W. (1995). "Phospholipid antitumor agents". Medicinal Research Reviews.

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experimental-cancer-drugs lipids

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