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Aleph-4

Field	Value
image	Aleph-4 v2.svg
image_class	skin-invert-image
routes_of_administration	Oral
class	Serotonergic psychedelic; Hallucinogen
ATC_prefix	None
duration_of_action	12–20 hours
CAS_number	123643-26-5
PubChem	44350301
ChemSpiderID	21500994
UNII	PJ4M669KSV
ChEMBL	127653
synonyms	ALEPH-4; DOT-4; 4-Isopropylthio-2,5-dimethoxyamphetamine; 2,5-Dimethoxy-4-isopropylthioamphetamine; 4-iPrS-DMA
IUPAC_name	1-(2,5-dimethoxy-4-propan-2-ylsulfanylphenyl)propan-2-amine
C	14	H=23	N=1	O=2	S=1
SMILES	CC(C)SC1=C(C=C(C(=C1)OC)CC(C)N)OC
StdInChI	1S/C14H23NO2S/c1-9(2)18-14-8-12(16-4)11(6-10(3)15)7-13(14)17-5/h7-10H,6,15H2,1-5H3
StdInChIKey	BCWCXWKCQMBFBQ-UHFFFAOYSA-N

| Drugs.com =

| elimination_half-life =

Aleph-4, or ALEPH-4, also known as 4-isopropylthio-2,5-dimethoxyamphetamine, is a psychedelic drug of the phenethylamine, amphetamine, and DOx families. It is one of the Aleph series of compounds. In his book PiHKAL (Phenethylamines I Have Known and Loved), Alexander Shulgin lists Aleph-4's dose as 7 to 12mg orally and its duration as 12 to 20hours. The effects of Aleph-4 have been reported to include closed-eye imagery, enhanced visual appreciation, emotional changes, and physical side effects and toxicity indications, among others. One of the reports remarked that it was "one of the most profound and deep learning experiences" they had had. However, Shulgin was unwilling to push the dose higher than 12mg due to toxicity concerns. The chemical synthesis of Aleph-4 has been described. Aleph-4 was first described in the scientific literature by Shulgin, David E. Nichols, Peyton Jacob III, and other colleagues in 1978. Subsequently, it was described in greater detail by Shulgin in PiHKAL in 1991. The drug was encountered as a novel designer drug in Japan in 2009. It is a Schedule I controlled substance in the United States as an isomer of 2C-T-7. The drug is also a controlled substance in Canada under phenethylamine blanket-ban language.

References

{{CitePiHKALhttps://erowid.org/library/books_online/pihkal/pihkal005.shtml
(1978). "QuaSAR: Quantitative Structure Activity Relationships Of Analgesics, Narcotic Antagonists, And Hallucinogens". National Institute on Drug Abuse.
Suzuki, J., Moriyasu, T., Nagashima, M., Kanai, C., Shimizu, M., Hamano, T., & Nagayama, T. (2010). Analysis of uncontrolled drugs purchased in fiscal year 2009. Ann RepTokyo Metrop Inst Public Health [Japanese: Tōkyō-to Kenkō Anzen Kenkyū Sentā Kenkyū Nenpō], 61, 163–172. https://isomerdesign.com/bitnest/external/TokyoMetr.Inst.PH/61.163
(February 2010). "2008年度買い上げ違法ドラッグ製品から検出された新規流通デザイナードラッグの同定". Yakugaku Zasshi.
(January 2026). "Orange Book: List of Controlled Substances and Regulated Chemicals (January 2026)". U.S. [[Department of Justice]]: [[Drug Enforcement Administration]] (DEA): Diversion Control Division.
"Controlled Drugs and Substances Act".

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designer-drugs dox-(psychedelics) isopropylthio-compounds pihkal psychedelic-phenethylamines

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