Surf Wiki
Save to docs
general/ec-1-4-1

From Surf Wiki (app.surf) — the open knowledge base

Alanine dehydrogenase

FieldValue
Namealanine dehydrogenase
EC_number1.4.1.1
CAS_number9029-06-5
GO_code0000286

Alanine dehydrogenase () is an enzyme that catalyzes the chemical reaction

The three substrates of this enzyme are alanine, water, and oxidised nicotinamide adenine dinucleotide (NAD+). Its products are pyruvic acid, reduced NADH, ammonia, and a proton.

This enzyme participates in taurine and hypotaurine metabolism and reductive carboxylate cycle ( fixation).

Nomenclature

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-NH2 group of donors with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is L-alanine:NAD+ oxidoreductase (deaminating). Other names in common use include AlaDH, L-alanine dehydrogenase, NAD+-linked alanine dehydrogenase, alpha-alanine dehydrogenase, NAD+-dependent alanine dehydrogenase, alanine oxidoreductase, and NADH-dependent alanine dehydrogenase. T

Structure

Alanine dehydrogenase contains both a N-terminus and C-terminus domains.

References

References

  1. {{KEGG enzyme. 1.4.1.1
  2. (March 1961). "The substrate specificity of L-alanine dehydrogenase". Biochimica et Biophysica Acta.
  3. (February 1965). "Enzymic properties of alanine dehydrogenase of Bacillus subtilis". Biochimica et Biophysica Acta (BBA) - Enzymology and Biological Oxidation.
  4. {{Pfam. PF05222
  5. {{Pfam. PF01262
  6. (2008). "Crystal structures of the Mycobacterium tuberculosis secretory antigen alanine dehydrogenase (Rv2780) in apo and ternary complex forms captures "open" and "closed" enzyme conformations". Proteins.
Info: Wikipedia Source

This article was imported from Wikipedia and is available under the Creative Commons Attribution-ShareAlike 4.0 License. Content has been adapted to SurfDoc format. Original contributors can be found on the article history page.

ec-1.4.1 nadh-dependent-enzymes enzymes-of-known-structure
Want to explore this topic further?

Ask Mako anything about Alanine dehydrogenase — get instant answers, deeper analysis, and related topics.

Research with Mako

Free with your Surf account

Content sourced from Wikipedia, available under CC BY-SA 4.0.

This content may have been generated or modified by AI. CloudSurf Software LLC is not responsible for the accuracy, completeness, or reliability of AI-generated content. Always verify important information from primary sources.

Report