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Akuammine

Akuammine (vincamajoridine) is an indole alkaloid. It is the most abundant alkaloid found in the seeds from the tree Picralima nitida, commonly known as akuamma, comprising 0.56% of the dried powder. It has also been isolated from Vinca major. Akuammine is structurally related to yohimbine, mitragynine and more distantly Voacangine, all of which are alkaloid plant products with pharmacological properties.

Pharmacology

Akuammine has antimalarial activity,

Akuammine is an opioid agonist with low affinity, selective for the mu-opioid receptor, when tested in vitro.

References

References

  1. "[[Merck Index]]".
  2. (September 1955). "The identity of vincamajoridine and akuammine". Experientia.
  3. (December 1993). "Akuammine: an antimalarial indolemonoterpene alkaloid of Picralima nitida seeds". Planta Medica.
  4. (1996). "African Ethnobotany: Poisons and Drugs : Chemistry, Pharmacology, Toxicology". CRC Press.
  5. (May 1998). "Opioid activity of alkaloids extracted from Picralima nitida (fam. Apocynaceae)". European Journal of Pharmacology.
  6. (March 1992). "Akuammine and dihydroakuammine, two indolomonoterpene alkaloids displaying affinity for opioid receptors". Journal of Natural Products.
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tryptamine-alkaloids alkaloids-found-in-apocynaceae hydroxyarenes carbazoles carboxylate-esters methyl-esters mu-opioid-receptor-antagonists
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