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Aildenafil

Chemical compound

Field	Value
drug_name	Aildenafil
image	Aildenafil.svg
image_class	skin-invert-image
legal_status	In general, unapproved and unscheduled; Rx in China
CAS_number	496835-35-9
PubChem	135452876
ChemSpiderID	8316620
UNII	9T49W8GAX6
synonyms	Methisosildenafil; Dimethyl sildenafil
IUPAC_name	5-[5-[(3S,5R)-3,5-dimethylpiperazin-1-yl]sulfonyl-2-ethoxyphenyl]-1-methyl-3-propyl-6H-pyrazolo[4,3-d]pyrimidin-7-one
C	23	H=32	N=6	O=4	S=1
SMILES	CCCC1=NN(C2=C1N=C(NC2=O)C3=C(C=CC(=C3)S(=O)(=O)N4C[C@H](NC@HC)C)OCC)C
StdInChI	1S/C23H32N6O4S/c1-6-8-18-20-21(28(5)27-18)23(30)26-22(25-20)17-11-16(9-10-19(17)33-7-2)34(31,32)29-12-14(3)24-15(4)13-29/h9-11,14-15,24H,6-8,12-13H2,1-5H3,(H,25,26,30)/t14-,15+
StdInChIKey	NFSWSZIPXJAYLR-GASCZTMLSA-N

| Drugs.com =

| elimination_half-life =

Aildenafil (methisosildenafil) is a synthetic drug that is a structural analog of sildenafil (Viagra). It was first reported in 2003. Like sildenafil, aildenafil is a phosphodiesterase type 5 inhibitor.

Aildenafil has been found as an adulterant in a variety of supplements which are sold as "natural" or "herbal" sexual enhancement products. The United States Food and Drug Administration has warned consumers that any sexual enhancement product that claims to work as well as prescription products is likely to contain such a contaminant.

Aildenafil is approved for use in China.

References

(2009). "Pharmacokinetics and safety of aildenafil tablets in healthy Chinese male subjects after multiple dose administration". Zhongguo Linchuang Yaolixue Zazhi.
"New compounds for treating impotence".
(April 2009). "Detection of undeclared erectile dysfunction drugs and analogues in dietary supplements by ion mobility spectrometry". [[Journal of Pharmaceutical and Biomedical Analysis]].
(2008). "Determination of analogs of sildenafil and vardenafil in foods by column liquid chromatography with a photodiode array detector, mass spectrometry, and nuclear magnetic resonance spectrometry". Journal of AOAC International.
(August 2007). "Use of liquid chromatography-mass spectrometry and a chemical cleavage reaction for the structure elucidation of a new sildenafil analogue detected as an adulterant in an herbal dietary supplement". Journal of Pharmaceutical and Biomedical Analysis.
(April 2007). "Structure elucidation of a novel analogue of sildenafil detected as an adulterant in an herbal dietary supplement". Journal of Pharmaceutical and Biomedical Analysis.
[https://web.archive.org/web/20100707070750/http://www.fda.gov/Safety/Recalls/EnforcementReports/ucm217780.htm Enforcement Report for June 30, 2010], [[United States Food and Drug Administration]]
[https://web.archive.org/web/20090603045259/http://www.fda.gov/ForConsumers/ConsumerUpdates/ucm048386.htm Hidden Risks of Erectile Dysfunction "Treatments" Sold Online], [[United States Food and Drug Administration]], February 21, 2009
(January 19, 2022). "First China-made drug for erectile dysfunction launched". China Daily.

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designer-drugs pde5-inhibitors sulfonamides

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