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African histoplasmosis

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name	African histoplasmosis
image	African histoplasmosis hariadhi.svg
specialty

African histoplasmosis is a fungal infection caused by Histoplasma capsulatum var. duboisii, or Histoplama duboisii (Hcd). Disease has been most often reported in Uganda, Nigeria, Zaire (Democratic Republic of the Congo) and Senegal, as Hcd is exclusive to Africa. In human disease it manifests differently than histoplasmosis (caused by Histoplasma capsulatum, or Hcc), most often involving the skin and bones and rarely involving the lungs. Also unlike Hcc, Hcd has been reported to rarely present in those with HIV, likely due to underreporting. However, this along with the differences in Hcc and Hcd have been disputed.

The favored locations of African histoplasmosis are "osteoarticular, ganglionic and pulmonary". Genitourinary skin damage is rare, occurring in only 4-11% patients and typically as a secondary skin invasion in those with disseminated infection.

It presents as "localized with isolated skin, bone, or lymph node infections or disseminated with multiple cutaneous lesions present all over the body, subcutaneous abscesses, enlarged lymph nodes, liver and spleen, and visceral organ enlargement" Cutaneous manifestations can be isolated or present with nodules, papules, or ulcers. They may present with subcutaneous swelling, cold abscesses progressing to spontaneous fistulization, or ulcers that may bud. If left alone, lesions may turn into a large ulcer.

References

(2006). "Andrews' Diseases of the Skin: clinical Dermatology". Saunders Elsevier.
(January 2018). "African histoplasmosis: new clinical and microbiological insights". Medical Mycology.
(November 2000). "Histoplasmosis in Africa: a review". The Indian Journal of Chest Diseases & Allied Sciences.
(28 August 2014). "Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases". Elsevier Health Sciences.
(1990-03-01). "Is African histoplasmosis an opportunistic fungal infection in AIDS?". Transactions of the Royal Society of Tropical Medicine and Hygiene.
(July 1995). "[African histoplasmosis due to Histoplasma capsulatum var. duboisii: relationship with AIDS in recent Congolese cases]". Santé.
(January 2006). "Histoplasmosis among human immunodeficiency virus-infected people in Europe: report of 4 cases and review of the literature". Medicine.
(June 2020). "African histoplasmosis of the penis". Oxford Medical Case Reports.
(2017). "Histoplasmosis by ''Histoplasma capsulatum'' var. duboisii Observed at the Laboratory of Pathological Anatomy of Lomé in Togo". Journal of Pathogens.
(April 2020). "African histoplasmosis in a Guinea Bissau patient with HIV-2: Case report and review". Journal de Mycologie Médicale.
(June 2009). "Histoplasma capsulatum recovery from the urine and a short review of genitourinary histoplasmosis". Mycopathologia.
(April 2015). "Primary cutaneous histoplasmosis developed in the penis of an immunocompetent patient". Anais Brasileiros de Dermatologia.
(June 2007). "Penoscrotal histoplasmosis following bladder carcinoma". International Journal of Urology.
(September 2017). "Scrotal Histoplasmosis Masquerading as Fournier's Gangrene". International Journal of Surgical Pathology.

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mycosis-related-cutaneous-conditions

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