Surf Wiki
Save to docs
general/antiprotozoal-agents

From Surf Wiki (app.surf) — the open knowledge base

Acetarsol

Acetarsol (or acetarsone, also known as spirocid) is an anti-infective drug. It was first discovered in 1921 at Pasteur Institute by Ernest Fourneau, and sold under the brand name Stovarsol. It was available in oral form and also as a suppository. It has been cancelled and withdrawn from the market since August 12, 1997.

Acetarsol can be used to make arsthinol.

Medical uses

Acetarsol has been used for the treatment of diseases such as syphilis, amoebiasis, yaws, trypanosomiasisiasis and malaria. Acetarsol was used for the treatment of Trichomonas Vaginalis and Candida Albicans. In the oral form, acetarsol can be used for the treatment of intestinal amoebiasis. As a suppository, acetarsol was researched to be used for the treatment of proctitis.

Mechanism of action

Although the mechanism of action is not fully known, acetarsol may bind to protein-containing sulfhydryl groups located in the parasite, which then creates lethal As-S bonds, which then kills the parasite.

Chemistry and pharmacokinetics

Acetarsol has the molecular formula N-acetyl-4-hydroxy-m-arsinillic acid, and it is a pentavalent arsenical compound with antiprotozoal and anthelmintic properties. The arsenic found in acetarsol is excreted mainly in urine. The level of arsenic after acetarsol administration reaches close to the toxic range in urine. Some reports indicate a remission of arsenic which can be physiologically dangerous.

Toxicity

Some reports indicate that acetarsol can produce effects in the eyes such as optic neuritis and optic atrophy.

References

References

  1. "FDA Substance Registration System: Acetarsol".
  2. (1932). "Stovarsol in the Treatment of Syphilis in Infants and in Children". American Journal of Diseases of Children.
  3. (April 1999). "Acetarsol pessaries in the treatment of metronidazole resistant Trichomonas vaginalis". Int J STD AIDS.
  4. PubChem. "Acetarsol".
  5. "Éric Fouassier, ''Ces poisons qui guérissent'', oct. 1996, p. 5.".
  6. ''Traité de chimie organique'', sous la direction de Victor Grignard, Paul Baud, vol. 22, Masson, 1959, p. 1127-1130.
  7. (October 2004). "Review article: problematic proctitis and distal colitis". Aliment. Pharmacol. Ther..
  8. PubChem. "Acetarsol".
Info: Wikipedia Source

This article was imported from Wikipedia and is available under the Creative Commons Attribution-ShareAlike 4.0 License. Content has been adapted to SurfDoc format. Original contributors can be found on the article history page.

antiprotozoal-agents acetanilides arsonic-acids phenols
Want to explore this topic further?

Ask Mako anything about Acetarsol — get instant answers, deeper analysis, and related topics.

Research with Mako

Free with your Surf account

Content sourced from Wikipedia, available under CC BY-SA 4.0.

This content may have been generated or modified by AI. CloudSurf Software LLC is not responsible for the accuracy, completeness, or reliability of AI-generated content. Always verify important information from primary sources.

Report