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AB-PINACA

Chemical compound

Chemical compound

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AB-PINACA is a compound that was first identified as a component of synthetic cannabis products in Japan in 2012.

It was originally developed by Pfizer in 2009 as an analgesic medication.

AB-PINACA acts as a potent agonist for the CB1 receptor (Ki = 2.87 nM, EC50 = 1.2 nM) and CB2 receptor (Ki = 0.88 nM, EC50 = 2.5 nM) and fully substitutes for Δ9-THC in rat discrimination studies, while being 1.5x more potent.

There have been a number of reported cases of deaths and hospitalizations in relation to this synthetic cannabinoid.

References

References

  1. Anvisa. (2023-07-24). "RDC Nº 804 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial". [[Diário Oficial da União]].
  2. (2012). "New cannabimimetic indazole derivatives, ''N''-(1-amino-3-methyl-1-oxobutan-2-yl)-1-pentyl-1''H''-indazole-3-carboxamide (AB-PINACA) and ''N''-(1-amino-3-methyl-1-oxobutan-2-yl)-1-(4-fluorobenzyl)-1''H''-indazole-3-carboxamide (AB-FUBINACA) identified as designer drugs in illegal products". Forensic Toxicology.
  3. "AB-PINACA". Cayman Chemical.
  4. "Indazole derivatives".
  5. (September 2015). "Pharmacology of Indole and Indazole Synthetic Cannabinoid Designer Drugs AB-FUBINACA, ADB-FUBINACA, AB-PINACA, ADB-PINACA, 5F-AB-PINACA, 5F-ADB-PINACA, ADBICA, and 5F-ADBICA". ACS Chemical Neuroscience.
  6. (September 2015). "AB-CHMINACA, AB-PINACA, and FUBIMINA: Affinity and Potency of Novel Synthetic Cannabinoids in Producing Δ9-Tetrahydrocannabinol-Like Effects in Mice". The Journal of Pharmacology and Experimental Therapeutics.
  7. (July 2015). "Synthetic Cannabinoid-Related Illnesses and Deaths". The New England Journal of Medicine.
  8. (September 2015). "Unintentional Pediatric Exposure to a Synthetic Cannabinoid (AB-PINACA) Resulting in Coma and Intubation". Annals of Emergency Medicine.
  9. "Gesetz über den Verkehr mit Betäubungsmitteln (Betäubungsmittelgesetz - BtMG) Anlage II (zu § 1 Abs. 1) (verkehrsfähige, aber nicht verschreibungsfähige Betäubungsmittel)".
  10. (30 April 2015). "Misuse of Drugs Act". Central Narcotics Bureau (CNB).
  11. (30 January 2015). "Schedules of controlled substances: Temporary placement of three synthetic cannabinoids into schedule I. Final order". Drug Enforcement Administration, U.S. Department of Justice.
  12. (27 September 2015). "关于印发《非药用类麻醉药品和精神药品列管办法》的通知". China Food and Drug Administration.
  13. (6 April 2017). "Arrêté du 31 mars 2017 modifiant l'arrêté du 22 février 1990 fixant la liste des substances classées comme stupéfiants". Legifrance.
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cannabinoids designer-drugs indazolecarboxamides cb1-receptor-agonists cb2-receptor-agonists
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