Skip to content
Surf Wiki
Save to docs
general/cannabinoids

From Surf Wiki (app.surf) — the open knowledge base

AB-FUBINACA

Chemical compound


Chemical compound

FieldValue
IUPAC_name*N*-[(2*S*)-1-Amino-3-methyl-1-oxobutan-2-yl]-1-[(4-fluorophenyl)methyl]indazole-3-carboxamide
imageAB-FUBINACA.svg
image_classskin-invert-image
width200px
pregnancy_AU
pregnancy_US
legal_AU
legal_BRF2
legal_BR_comment
legal_CASchedule II
legal_UKClass B
legal_USSchedule I
legal_DEAnlage II
legal_UNP II
legal_statusIllegal in China
CAS_number_Ref
CAS_number1185282-01-2
PubChem58124325
KEGGC22703
smilesCC(C)[C@H](NC(=O)c1nn(Cc2ccc(F)cc2)c3ccccc13)C(N)=O
ChemSpiderID28537614
UNIII7PZF0KTFK
StdInChI1S/C20H21FN4O2/c1-12(2)17(19(22)26)23-20(27)18-15-5-3-4-6-16(15)25(24-18)11-13-7-9-14(21)10-8-13/h3-10,12,17H,11H2,1-2H3,(H2,22,26)(H,23,27)/t17-/m0/s1
StdInChIKeyAKOOIMKXADOPDA-KRWDZBQOSA-N
C20H=21F=1N=4O=2

| elimination_half-life =

AB-FUBINACA (AMB-FUBINACA) is a psychoactive drug that acts as a potent agonist for the cannabinoid receptors, with Ki values of 0.9 nM at CB1 and 23.2 nM at CB2 and EC50 values of 1.8 nM at CB1 and 3.2 nM at CB2. It was originally developed by Pfizer in 2009 as an analgesic medication but was never pursued for human use. In 2012, it was discovered as an ingredient in synthetic cannabinoid blends in Japan, along with a related compound AB-PINACA, which had not previously been reported.

Its use has been linked to hospitalizations and deaths.

Legality

United States of America

It was designated as a Schedule I controlled substance in the United States in January 2014.

Finland

In Finland AB-FUBINACA is scheduled in government decree on psychoactive substances banned from the consumer market as of 19 October 2017.

Germany

It is an Anlage II controlled substance in Germany as of November 2014.

China

Since October 2015 AB-FUBINACA is a controlled substance in China.

Others

In December 2019, the UNODC announced scheduling recommendations placing AB-FUBINACA as a controlled research chemical into Schedule II. 101789

Mass overdoses due to adulterated K2

On August 15, 2018, 70 people within the city of New Haven, Connecticut, started overdosing near Yale University campus. By the end of the week, the total number of overdosed had risen to over 100 people needing transport to local emergency rooms. Three men were arrested, charged as drug dealers selling synthetic cannabis which contained AB-FUBINACA. First responders concluded that the overdoses were caused by opiate adulterants, as victims responded to Narcan. Almost all of the overdoses occurred on the New Haven Green, a large downtown park that is heavily traveled and very popular with the homeless population. There have been no deaths associated with these overdoses; however, several victims were in critical or life-threatening condition for a period of time.

References

References

  1. Anvisa. (2023-07-24). "RDC Nº 804 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial". [[Diário Oficial da União]].
  2. (March 2023). "EMCDDA framework and practical guidance for naming synthetic cannabinoids". Drug Testing and Analysis.
  3. (September 2015). "Pharmacology of Indole and Indazole Synthetic Cannabinoid Designer Drugs AB-FUBINACA, ADB-FUBINACA, AB-PINACA, ADB-PINACA, 5F-AB-PINACA, 5F-ADB-PINACA, ADBICA, and 5F-ADBICA". ACS Chemical Neuroscience.
  4. (April 2016). "Detection and Characterization of the Effect of AB-FUBINACA and Its Metabolites in a Rat Model". Journal of Cellular Biochemistry.
  5. (September 2016). "Identification of AB-FUBINACA metabolites in authentic urine samples suitable as urinary markers of drug intake using liquid chromatography quadrupole tandem time of flight mass spectrometry". Drug Testing and Analysis.
  6. "Indazole Derivatives".
  7. (January 2013). "New cannabimimetic indazole derivatives, N-(1-amino-3-methyl-1-oxobutan-2-yl)-1-pentyl-1H-indazole-3-carboxamide (AB-PINACA) and N-(1-amino-3-methyl-1-oxobutan-2-yl)-1-(4-fluorobenzyl)-1H-indazole-3-carboxamide (AB-FUBINACA) identified as designer drugs in illegal products". Forensic Toxicology.
  8. (July 2015). "Synthetic Cannabinoid-Related Illnesses and Deaths". The New England Journal of Medicine.
  9. (August 2016). "Suicide attempt with a mix of synthetic cannabinoids and synthetic cathinones: Case report of non-fatal intoxication with AB-CHMINACA, AB-FUBINACA, alpha-PHP, alpha-PVP and 4-CMC". Forensic Science International.
  10. (10 January 2014). "Schedules of Controlled Substances: Temporary Placement of Four Synthetic Cannabinoids Into Schedule I". Drug Enforcement Administration, Department of Justice.
  11. "FINLEX ® - Säädökset alkuperäisinä: Valtioneuvoston asetus kuluttajamarkkinoilta… 698/2017".
  12. "Gesetz über den Verkehr mit Betäubungsmitteln (Betäubungsmittelgesetz - BtMG) Anlage II (zu § 1 Abs. 1) (verkehrsfähige, aber nicht verschreibungsfähige Betäubungsmittel)".
  13. (27 September 2015). "关于印发《非药用类麻醉药品和精神药品列管办法》的通知". China Food and Drug Administration.
  14. "December 2019 – WHO: World Health Organization recommends 12 NPS for scheduling".
  15. (2018-08-15). "New Haven Overdoses Tied to Laced K2". The New York Times.
  16. (17 August 2018). "Police Arrest Third Suspect In New Haven Synthetic Marijuana Overdose Case". NPR.
  17. (16 August 2018). "Dozens Overdose In Connecticut Park On Tainted Synthetic Marijuana". NPR.
  18. (18 August 2018). "New Haven police make arrest after more than 100 K2 overdose calls". CNN.
  19. (2018-08-15). "New Haven Overdoses Tied to Laced K2". The New York Times.
  20. (17 August 2018). "Police Arrest Third Suspect In New Haven Synthetic Marijuana Overdose Case". NPR.
Info: Wikipedia Source

This article was imported from Wikipedia and is available under the Creative Commons Attribution-ShareAlike 4.0 License. Content has been adapted to SurfDoc format. Original contributors can be found on the article history page.

Want to explore this topic further?

Ask Mako anything about AB-FUBINACA — get instant answers, deeper analysis, and related topics.

Research with Mako

Free with your Surf account

Content sourced from Wikipedia, available under CC BY-SA 4.0.

This content may have been generated or modified by AI. CloudSurf Software LLC is not responsible for the accuracy, completeness, or reliability of AI-generated content. Always verify important information from primary sources.

Report