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AB-005

Group of stereoisomers

Group of stereoisomers

| elimination_half-life =

AB-005 or 1-[(1-methylpiperidin-2-yl)methyl]-1H-indol-3-yl-methanone is a designer drug offered by online vendors as a cannabimimetic agent. The structure and pharmacological activity of AB-005 was published in 2010, prior to its commercial availability in 2012, where it was reported to have high affinity for both CB1 (Ki = 5.5 nM) and CB2 receptors (Ki = 0.48 nM). AB-005 features groups found in other previously reported synthetic cannabinoids: the tetramethylcyclopropane group of UR-144 and XLR-11 as well as the (1-methyl-2-piperidinyl)methyl substituent of AM-1248 and AM-1220. No information regarding the in vivo activity of AB-005 has been published, and only anecdotal reports are known of its psychoactivity in humans.

References

References

  1. "Interim Product Approvals". [[Ministry of Health (New Zealand).
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cannabinoids designer-drugs tetramethylcyclopropanoylindoles piperidines
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